INT183062

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.28
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (SHH) endoplasmic reticulum (SHH) embryo development (SHH)
cell-cell signaling (SHH) signal transducer activity (SHH) peptidase activity (SHH)
Anatomy Link Frequency
notochord 2
liver 1
neural 1
cerebellum 1
stage 4 1
SHH (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 5 85.80 High High
fibrosis 12 58.04 Quite High
anesthesia 18 51.44 Quite High
potassium channel 1 50.52 Quite High
Neurotransmitter 6 48.32 Quite Low
alcohol 4 39.04 Quite Low
Dopamine 2 13.44 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 268 98.28 Very High Very High Very High
Rheumatoid Arthritis 52 95.48 Very High Very High Very High
Repression 9 93.68 High High
Medulloblastoma 30 86.72 High High
Chordoma 262 85.92 High High
Fibrosis 8 85.68 High High
Disease 48 82.76 Quite High
Solid Tumor 4 79.64 Quite High
Pancreatic Cancer 36 77.84 Quite High
Infection 10 72.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The consensus region for gains on chromosome 7q was 7q36, where the homeobox gene HLXB9 and sonic hedgehog gene SHH reside: interestingly both genes are a plausible candidate as they are expressed throughout the notochord during embryogenesis [67].
Gene_expression (reside) of SHH in notochord
1) Confidence 0.65 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 0.52 Pain Relevance 0
The consensus region for gains on chromosome 7q was 7q36, where the homeobox gene HLXB9 and sonic hedgehog gene SHH reside: interestingly both genes are a plausible candidate as they are expressed throughout the notochord during embryogenesis [67].
Gene_expression (reside) of sonic hedgehog in notochord
2) Confidence 0.65 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 0.53 Pain Relevance 0
However, we did not detect NS expression of genes encoding Hh ligands like Shh (Figure 3B), similar to previous studies [19].
Gene_expression (expression) of Shh
3) Confidence 0.55 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.24 Pain Relevance 0.04
We were unable to replicate the remaining loci (SHH and two loci on chromosomes 5p15.33 and 15q14) in these reports, probably because most of these associated SNPs are either non-polymorphic or possess very low allelic frequencies (MAF?
Gene_expression (loci) of SHH
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912284 Disease Relevance 0.52 Pain Relevance 0.03
To test directly whether the absence of Hh signaling was required for expression of endodermal or islet markers, including FoxA3, Pdx1, and insulin, we added Shh protein to stage 4 cultures, which do not express Shh or genes encoding other Hh ligands like Desert hedgehog or Indian hedgehog (Figure 3C).
Gene_expression (ligands) of hedgehog in stage 4
5) Confidence 0.48 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.23 Pain Relevance 0.03
We detected expression of the Hedgehog receptors Patched (Ptc) and Smoothened (Smo) at all stages (Figure 3B), consistent with the possibility that NS-derived cells are competent for Hh signaling.
Gene_expression (expression) of Hedgehog
6) Confidence 0.48 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.27 Pain Relevance 0.04
Tumor growth is a tissue-level quantity is regulated by a hierarchy of steps starting with Shh expression and hedgehog activation.
Gene_expression (expression) of Shh associated with cancer
7) Confidence 0.45 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.78 Pain Relevance 0
Total positive associations (AUC-ROC, 1.000) were found between IHH and three of the five expressed genes (SHH, GLI1, and GLI4).


Gene_expression (expressed) of SHH
8) Confidence 0.44 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.30 Pain Relevance 0.05
To further explore the Hedgehog-Gli signaling pathway to discriminate between groups A and B, we tested the expression of six additional genes involved in this pathway (DHH, SHH, GLI1, GLI2, GLI3, and GLI4) in three high IHH-expressing percutaneous normal liver samples and three low IHH-overexpressing surgical nontumoral liver samples.
Gene_expression (expression) of SHH in liver
9) Confidence 0.44 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.63 Pain Relevance 0.03
Shh does not have production or decay reactions; it is set either to either its lowest or highest value in simulations.
Gene_expression (production) of Shh
10) Confidence 0.39 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.57 Pain Relevance 0
The Gli transcription factors are the primary effectors of Shh signalling in the developing cerebellum [30,35].
Gene_expression (effectors) of Shh in cerebellum
11) Confidence 0.39 Published 2007 Journal BMC Syst Biol Section Body Doc Link PMC1839891 Disease Relevance 0.60 Pain Relevance 0
More interestingly, in comparison of genes associated during neural differentiation process of human embryonic stem cells or human brain with our results, we also found increased expression of PENK, STK4, IGFBP4, Slc17a6, Slc6A1, Nurr1, Nrp2, Moxd1, Shh and Neurod2 [36,37].
Gene_expression (expression) of Shh in neural
12) Confidence 0.24 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0

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