INT183065

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.58
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDX1) generation of precursor metabolites and energy (PDX1) nucleus (PDX1)
cytoplasm (PDX1)
Anatomy Link Frequency
epithelial cell 2
connective tissue 2
stage 3 2
stage 4 2
PDX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 571 100.00 Very High Very High Very High
corticosteroid 16 97.52 Very High Very High Very High
Spinal cord 3 90.28 High High
Inflammation 22 34.60 Quite Low
cva 2 23.68 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Thoracotomy 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Idiopathic Pulmonary Fibrosis 571 100.00 Very High Very High Very High
Secondary Pulmonary Hypertension 18 100.00 Very High Very High Very High
Rheumatoid Arthritis 57 99.98 Very High Very High Very High
Pulmonary Disease 80 99.90 Very High Very High Very High
Interstitial Lung Diseases 78 94.48 High High
Disease 89 92.44 High High
Pneumonia 8 81.56 Quite High
Hyperglycemia 9 81.24 Quite High
Injury 13 76.92 Quite High
Embryonal Carcinoma 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pdx1, Cdx1, and FoxA3 expression was induced in “stage 3,” when cell clusters were allowed to adhere to pre-coated wells at a density of 40–80 NSs/cm2 and cultured in low-glucose medium with 2 ?
Positive_regulation (induced) of Gene_expression (expression) of Pdx1 in stage 3
1) Confidence 0.54 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 1.00 Pain Relevance 0
To elucidate the mechanisms underlying RA-induced expression of markers like FoxA3 and Pdx1, we examined Hh signaling during IPC development.
Positive_regulation (induced) of Gene_expression (expression) of Pdx1 associated with rheumatoid arthritis
2) Confidence 0.39 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.28 Pain Relevance 0.05
To test directly whether the absence of Hh signaling was required for expression of endodermal or islet markers, including FoxA3, Pdx1, and insulin, we added Shh protein to stage 4 cultures, which do not express Shh or genes encoding other Hh ligands like Desert hedgehog or Indian hedgehog (Figure 3C).
Spec (whether) Positive_regulation (required) of Gene_expression (expression) of Pdx1 in stage 4
3) Confidence 0.39 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.20 Pain Relevance 0.03
The definite diagnosis of IPF requires all of the following: [1]

• Surgical lung biopsy revealing a histologic pattern consistent with UIP • Exclusion of other known causes of interstitial lung disease (e.g.: connective tissue disease, environmental exposure, etc.) • Abnormal pulmonary physiology with evidence of restriction and/or impaired gas exchange (can exist during exercise alone) • HRCT demonstrating a pattern of "confident" or "possible" IPF.

Positive_regulation (requires) of Gene_expression (diagnosis) of IPF in connective tissue associated with fibrosis, interstitial lung diseases, idiopathic pulmonary fibrosis and disease
4) Confidence 0.38 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.85 Pain Relevance 0.41
Pulmonary hypertension and IPF
Positive_regulation (hypertension) of Gene_expression (hypertension) of IPF associated with secondary pulmonary hypertension and fibrosis
5) Confidence 0.38 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2330030 Disease Relevance 1.90 Pain Relevance 0.56
The remaining cells coexpress either insulin, or epithelial cell markers [5] or pancreatic and duodenal homeobox gene-1 (PDX-1), which regulates glucose-stimulated insulin gene expression [9].
Positive_regulation (glucose-stimulated) of Gene_expression (expression) of PDX-1 in epithelial cell
6) Confidence 0.27 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0.28 Pain Relevance 0
These cells expressed transcription factors pdx-1, pax-6, and isl-1, all three are central controlling genes capable of reprogramming nonpancreatic cells to surrogate ?
Positive_regulation (factors) of Gene_expression (expressed) of pdx-1
7) Confidence 0.20 Published 2010 Journal Stem Cells International Section Body Doc Link PMC3010655 Disease Relevance 0.25 Pain Relevance 0
positive areas (Epi+Int and Epi) between the control, COPD and IPF groups differed significantly (Kruskal Wallis test; p = 0.007) while the Hb?
Positive_regulation (while) of Gene_expression (groups) of IPF associated with fibrosis and pulmonary disease
8) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.81 Pain Relevance 0.24

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