INT183066

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.31
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
hepatocytes 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
transdermal 13 97.24 Very High Very High Very High
Inflammation 68 83.12 Quite High
cytokine 26 82.08 Quite High
Somatostatin 5 42.48 Quite Low
tolerance 12 10.16 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
iatrogenic 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 6 100.00 Very High Very High Very High
Weight Loss 23 99.72 Very High Very High Very High
Obesity 228 95.12 Very High Very High Very High
Parkinson's Disease 23 88.40 High High
Insulin Resistance 50 87.20 High High
Diabetes Mellitus 233 83.52 Quite High
INFLAMMATION 69 83.12 Quite High
Hyperglycemia 9 82.32 Quite High
Apoptosis 5 79.44 Quite High
Cancer 11 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coinciding with the onset of high insulin expression levels in mouse islets, ngn3 expression is virtually extinguished [25], while expression of Pdx1, FoxA3, Isl1, and Nkx6.1 in islet ?
Positive_regulation (high) of Transcription (levels) of insulin associated with hyperinsulinism
1) Confidence 0.49 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.34 Pain Relevance 0
RT–PCR analysis comparing Srebp-1c, Ppard, Ppara, Ins (proinsulin), Ucp-2, Ampk and Gck mRNA expression in BRIN-BD11 cells treated in the absence or presence of increasing concentrations of AA for 24 h was performed.
Positive_regulation (comparing) of Transcription (expression) of proinsulin
2) Confidence 0.49 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
Furthermore, a recent report also indicated that while a low-calorie diet substantially enhanced insulin sensitivity (e.g., ?
Positive_regulation (enhanced) of Transcription (sensitivity) of insulin
3) Confidence 0.46 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 1.17 Pain Relevance 0
Furthermore, a recent report also indicated that while a low-calorie diet substantially enhanced insulin sensitivity (e.g., ?
Positive_regulation (indicated) of Transcription (sensitivity) of insulin
4) Confidence 0.46 Published 2010 Journal Diabetes Section Body Doc Link PMC2797949 Disease Relevance 1.19 Pain Relevance 0
In work previously performed on syngeneic murine primary hepatocytes [19], we showed that high glucose concentration stimulated insulin transcription from a bifunctional promoter in p3MTCHins, consisting of the human metallothionein IIA promoter linked to a carbohydrate response element [20], within 6–10 minutes and secretion within 12 minutes.
Positive_regulation (stimulated) of Transcription (transcription) of insulin in hepatocytes
5) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249706 Disease Relevance 0.39 Pain Relevance 0
They found that applied bipolar DC current profiles could enhance the absorption of the insulin and calcitonin.
Positive_regulation (enhance) of Transcription (absorption) of insulin
6) Confidence 0.35 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2527667 Disease Relevance 0 Pain Relevance 0.08
Insulin transcription increased 1.5-fold within 5 min in 25 mM glucose, and decreased by about 8-fold within 10 min of restoring glucose concentration to 2.5 mM (Figure 1E).


Positive_regulation (increased) of Transcription (transcription) of Insulin
7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249706 Disease Relevance 0.24 Pain Relevance 0
The magnitude of the improvement in insulin sensitivity after weight loss was significantly correlated with decreases in serum A-SAA (

r = ?

Positive_regulation (improvement) of Transcription (sensitivity) of insulin associated with weight loss
8) Confidence 0.13 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1472697 Disease Relevance 1.99 Pain Relevance 0.27

General Comments

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