INT183068

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.27
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (SMO) plasma membrane (SMO) cilium (SMO)
cytoplasm (SMO) signal transducer activity (SMO)
Anatomy Link Frequency
DA neurons 2
brain 1
SMO (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 60 99.84 Very High Very High Very High
Dopamine 249 99.48 Very High Very High Very High
Action potential 12 86.56 High High
Spinal cord 1 85.80 High High
gABA 9 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 17 95.48 Very High Very High Very High
Neurodegenerative Disease 21 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Parkinson's Disease 4 5.00 Very Low Very Low Very Low
Nervous System Malformation 3 5.00 Very Low Very Low Very Low
Mucocutaneous Lymph Node Syndrome 3 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of the brain-derived neurotrophic factor receptor, TrkB, and the smoothened (SMO) receptor was also confirmed in SPIE treated cultures.
Gene_expression (expression) of SMO in brain
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.29
Increased expression of the brain-derived neurotrophic factor receptor, TrkB [39], [40], and the SMO receptor that is involved in SHH signaling [41], both of which are highly expressed in midbrain DA neurons, was also detected in SPIE-treated cultures.
Gene_expression (expression) of SMO receptor in DA neurons associated with dopamine and midbrain
2) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.44
Increased expression of the brain-derived neurotrophic factor receptor, TrkB [39], [40], and the SMO receptor that is involved in SHH signaling [41], both of which are highly expressed in midbrain DA neurons, was also detected in SPIE-treated cultures.
Gene_expression (expressed) of SMO receptor in DA neurons associated with dopamine and midbrain
3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.44
We detected expression of the Hedgehog receptors Patched (Ptc) and Smoothened (Smo) at all stages (Figure 3B), consistent with the possibility that NS-derived cells are competent for Hh signaling.
Gene_expression (expression) of Smoothened
4) Confidence 0.09 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.27 Pain Relevance 0.04

General Comments

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