INT183070

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PTCH1) Golgi apparatus (PTCH1) plasma membrane (PTCH1)
Anatomy Link Frequency
MCF-7 1
PTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 72.96 Quite High
Hsan 2 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 110 97.84 Very High Very High Very High
Cancer 55 96.64 Very High Very High Very High
Rheumatoid Arthritis 19 82.64 Quite High
Skin Cancer 32 5.00 Very Low Very Low Very Low
Basal Cell Nevus Syndrome 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 7 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Fanconi Anemia 4 5.00 Very Low Very Low Very Low
Pancreatic Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA expression of PHF2, FANCC, PTCH1 and XPA in normal breast tissue (n = 6), and primary BC (n = 14) and 1 cell line (MCF-7) was analyzed by quantitative real-time (Q-PCR).
Spec (analyzed) Transcription (expression) of PTCH1 in MCF-7 associated with breast cancer
1) Confidence 0.68 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.33 Pain Relevance 0
Q-PCR analysis of PHF2, FANCC and PTCH1 mRNA revealed reduced mRNA expression of in all these genes.
Transcription (expression) of PTCH1
2) Confidence 0.53 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.40 Pain Relevance 0
Increased Ptc transcription is a known consequence of Shh signaling, but we did not detect changes of Ptc expression during stages 1–4, consistent with the absence of detectable expression of Hh ligands.
Transcription (transcription) of Ptc
3) Confidence 0.38 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1087208 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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