INT183094

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Context Info
Confidence 0.09
First Reported 2005
Last Reported 2010
Negated 1
Speculated 6
Reported most in Body
Documents 14
Total Number 21
Disease Relevance 15.09
Pain Relevance 0.25

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Anatomy Link Frequency
BxPC-3 3
AsPC-1 3
HPAC 2
CFPAC-1 2
PSN1 1
Panc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 78 69.28 Quite High
Inflammation 14 5.00 Very Low Very Low Very Low
palliative 12 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 950 100.00 Very High Very High Very High
Adenocarcinoma 95 98.92 Very High Very High Very High
Cancer 672 98.68 Very High Very High Very High
Testicular Cancer 1 97.68 Very High Very High Very High
Neuroblastoma 1 95.64 Very High Very High Very High
Viral Infection 19 95.44 Very High Very High Very High
Colon Cancer 6 94.96 High High
Breast Cancer 9 94.32 High High
Apoptosis 152 92.60 High High
Lung Cancer 11 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the isoform of vimentin was only found in 4 of the cell lines analyzed (in the Panc-1 pancreatic, in the H23 and A549 lung adenocarcinoma, and in the Hs1 testes tumor cell lines), thus suggesting that expression of the antigenic isoform was cell line-specific.
Gene_expression (pancreatic) of Panc-1 in A549 associated with adenocarcinoma and testicular cancer
1) Confidence 0.09 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.97 Pain Relevance 0
Western Blot analysis discriminated cancer cell lines into MxA positive (PaCa44, HPAFI, CFPAC, PSN1) or MxA negative (Ger, PT45, Panc1, Panc2, MiaPaCa2, PaCa3) (Figure 5A).
Neg (negative) Gene_expression (negative) of Panc1 in PSN1 associated with cancer
2) Confidence 0.07 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.67 Pain Relevance 0
In contrast, Hsulf-1 expressing Panc-1 cells were more resistant to gemcitabine than the control cells, thereby suggesting that Hsulf-1 over-expression might confer increased chemoresistance to pancreatic cancer cells and thus provide them with a growth advantage.
Gene_expression (expressing) of Panc-1 associated with pancreatic cancer
3) Confidence 0.06 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.57 Pain Relevance 0.07
PDAC transduction by serial dilution of Ad-GFP resulted also in higher expression of GFP in lines not expressing MxA (Ger, PT45, Panc1, Panc2, MiaPaCa2) (Figure 5D and 5E).


Gene_expression (expression) of Panc1 associated with adenocarcinoma
4) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 1.03 Pain Relevance 0
Hsulf-1 decreases FGF-2 mediated cell proliferation and signaling in Panc-1 pancreatic cancer cells
Gene_expression (pancreatic) of Panc-1 associated with pancreatic cancer
5) Confidence 0.05 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.42 Pain Relevance 0
Functional consequences of Hsulf-1 expression in Panc-1 pancreatic cancer cells
Gene_expression (pancreatic) of Panc-1 associated with pancreatic cancer
6) Confidence 0.05 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.10 Pain Relevance 0
Panc-1 pancreatic cancer cells were stably transfected with the Hsulf-1 plasmid and with the empty control vector using the lipofectamine reagent [7,8].
Gene_expression (transfected) of Panc-1 associated with pancreatic cancer
7) Confidence 0.04 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.17 Pain Relevance 0
To confirm successful transfection of Panc-1 cells with the full-length Hsulf-1 construct, Northern blot analysis was carried out using a Hsulf-1 antisense riboprobe.
Gene_expression (transfection) of Panc-1
8) Confidence 0.04 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.72 Pain Relevance 0.18
For example, our results show lower expression of miR-155 in Panc-1 when compared to HPDE, even though most of the literature suggests this miRNA as being up-regulated in cancer and thus known as an oncogenic miRNA.
Gene_expression (expression) of Panc-1 associated with cancer
9) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.38 Pain Relevance 0
We examined midkine mRNA expression and midkine protein expression by seven human pancreatic cancer cell lines (AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, PANC-1, and Suit-2), as well as by non-cancerous pancreatic tissue and pancreatic cancers.
Spec (examined) Gene_expression (expression) of PANC-1 in HPAC associated with pancreatic cancer
10) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 0.77 Pain Relevance 0
Ad5MK showed much greater cytotoxicity for midkine-expressing Suit-2 and PANC-1 cell lines than for midkine-negative MIAPaCa-2 cell lines.
Gene_expression (-) of PANC-1 in PANC-1
11) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 0.82 Pain Relevance 0
AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, and PANC-1 cells were obtained from the American Type Culture Collection (Rockville, MD), and were maintained in the medium recommended by the ATCC at 37°C in a humidified atmosphere of 5% CO2.
Gene_expression (maintained) of PANC-1 in CFPAC-1
12) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.94 Pain Relevance 0
Western blot was used to determine constitutive FAK and pFAK (pY397) expression in four pancreatic cancer cell lines (BxPC-3, AsPC-1, MiaPaCa-2 and Panc-1) (Fig. 1A-B).
Spec (determine) Gene_expression (expression) of Panc-1 in AsPC-1 associated with pancreatic cancer
13) Confidence 0.02 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.41 Pain Relevance 0
Similar results were obtained in Panc-1 cells stably transfected with the FAK RNAi2 plasmid (data not shown).
Gene_expression (transfected) of Panc-1
14) Confidence 0.02 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.55 Pain Relevance 0
We examined midkine mRNA expression and midkine protein expression by seven human pancreatic cancer cell lines (AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, PANC-1, and Suit-2), as well as by non-cancerous pancreatic tissue and pancreatic cancers.
Spec (examined) Gene_expression (expression) of PANC-1 in BxPC-3 associated with pancreatic cancer
15) Confidence 0.01 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 0.77 Pain Relevance 0
We examined midkine mRNA expression and midkine protein expression by seven human pancreatic cancer cell lines (AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, PANC-1, and Suit-2), as well as by non-cancerous pancreatic tissue and pancreatic cancers.
Spec (examined) Gene_expression (expression) of PANC-1 in AsPC-1 associated with pancreatic cancer
16) Confidence 0.01 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 0.77 Pain Relevance 0
We examined midkine mRNA expression and midkine protein expression by seven human pancreatic cancer cell lines (AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, PANC-1, and Suit-2), as well as by non-cancerous pancreatic tissue and pancreatic cancers.
Spec (examined) Gene_expression (expression) of PANC-1 in CFPAC-1 associated with pancreatic cancer
17) Confidence 0.01 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 0.77 Pain Relevance 0
AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, and PANC-1 cells were obtained from the American Type Culture Collection (Rockville, MD), and were maintained in the medium recommended by the ATCC at 37°C in a humidified atmosphere of 5% CO2.
Gene_expression (maintained) of PANC-1 in BxPC-3
18) Confidence 0.01 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.94 Pain Relevance 0
AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, and PANC-1 cells were obtained from the American Type Culture Collection (Rockville, MD), and were maintained in the medium recommended by the ATCC at 37°C in a humidified atmosphere of 5% CO2.
Gene_expression (maintained) of PANC-1 in AsPC-1
19) Confidence 0.01 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.94 Pain Relevance 0
AsPC-1, BxPC-3, CFPAC-1, HPAC, MIAPaCa-2, and PANC-1 cells were obtained from the American Type Culture Collection (Rockville, MD), and were maintained in the medium recommended by the ATCC at 37°C in a humidified atmosphere of 5% CO2.
Gene_expression (maintained) of PANC-1 in HPAC
20) Confidence 0.01 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2529268 Disease Relevance 0.94 Pain Relevance 0

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