INT18311

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2011
Negated 4
Speculated 2
Reported most in Abstract
Documents 145
Total Number 147
Disease Relevance 113.48
Pain Relevance 19.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cells 66
lymphocytes 9
blood 7
NK cells 3
effector T cells 3
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.84 Very High Very High Very High
cINOD 45 99.80 Very High Very High Very High
Inflammation 1368 99.46 Very High Very High Very High
spastic colon 176 99.44 Very High Very High Very High
cytokine 1066 99.16 Very High Very High Very High
psoriasis 87 99.14 Very High Very High Very High
spinal inflammation 211 98.94 Very High Very High Very High
agonist 202 98.86 Very High Very High Very High
Multiple sclerosis 255 98.76 Very High Very High Very High
depression 31 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1269 100.00 Very High Very High Very High
Influenza Virus Infection 595 100.00 Very High Very High Very High
Hypergammaglobulinemia 3 100.00 Very High Very High Very High
Apoptosis 576 99.92 Very High Very High Very High
Leishmaniasis 750 99.84 Very High Very High Very High
Enteritis 12 99.78 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 1110 99.76 Very High Very High Very High
Lymphatic System Cancer 97 99.76 Very High Very High Very High
Infection 1075 99.74 Very High Very High Very High
Lymphocytosis 7 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fentanyl exposure under the conditions of this study caused a rapid and significant increase in natural killer cell cytotoxicity, which was coincident with an increase in the percentage of CD16(+) and CD8(+) cells in peripheral blood.
Positive_regulation (increase) of CD8 in blood
1) Confidence 0.69 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 11772808 Disease Relevance 0.15 Pain Relevance 0.30
In addition, we demonstrated an inverted correlation between beta-endorphins and VIP; 2) 30 minutes after acupuncture session, 80% of the treated patients showed a significant increase of CD3 and CD4 values and an increase of CD8 24 hours after stimulation; 3) Monocyte phagocytosis was increased in 45% of the treated subjects 30 minutes from starting treatment, and in 100% of them after 24 hours.
Positive_regulation (increase) of CD8 in Monocyte associated with acupuncture
2) Confidence 0.67 Published 1998 Journal J Tradit Chin Med Section Abstract Doc Link 10437265 Disease Relevance 0 Pain Relevance 0.50
Various explanations have been proposed including (a) the reduction of Langerhans' cells (LCs) in HIV disease, (b) the direct epidermal proliferative effect of HIV, (c) the altered cytokine profile in HIV disease, (d) HIV-induced macrophage nitric oxide (NO) production, (e) the increased CD8/CD4 T-cell ratio in HIV infection and (f) the increased colonization of skin by Staphylococcus aureus.
Positive_regulation (increased) of CD8 in skin associated with acquired immune deficiency syndrome or hiv infection, disease, infection and cytokine
3) Confidence 0.67 Published 2004 Journal Autoimmunity Section Abstract Doc Link 15115314 Disease Relevance 2.35 Pain Relevance 0.43
EMG activity in MAL and MAR was increased in the head back position compared to head rest and head right positions, whereas EMG activity in SCM and SP was progressively increased as the head was moved from rest position to head back to head right positions.
Positive_regulation (increased) of MAL in MAR
4) Confidence 0.67 Published 2004 Journal Pain Section Abstract Doc Link 15157682 Disease Relevance 0.40 Pain Relevance 0.59
The following laboratory abnormalities are seen with some frequency, although none are seen in all patients: lymphocytosis, atypical lymphocytosis, monocytosis, elevation of hepatocellular enzymes, low levels of antinuclear antibodies, varying levels of antithyroid antibodies, partial hypergammaglobulinemia, elevated CD4:CD8 ratio, decreased cytolytic activity of natural killer cells, and low levels of immune complexes.
Positive_regulation (elevation) of CD8 in natural killer cells associated with hypergammaglobulinemia, congenital anomalies and lymphocytosis
5) Confidence 0.67 Published 1989 Journal J Rheumatol Suppl Section Abstract Doc Link 2691680 Disease Relevance 1.38 Pain Relevance 0.07
However, patients in the four highest dose groups (ddI at 1.6 milligrams per kilogram intravenously and then greater than or equal to 3.2 milligrams per kilogram orally at least every 12 hours or higher) had increases in their circulating CD4+ T cells (P less than 0.0005), increased CD4/CD8 T cell ratios (P less than 0.01), and, where evaluable, more than an 80% decrease in serum HIV p24 antigen (P less than 0.05).
Positive_regulation (increased) of CD8 in T cell associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.67 Published 1989 Journal Science Section Abstract Doc Link 2502840 Disease Relevance 0.97 Pain Relevance 0.06
In our study, the levels of CD8+ CD28- T cells were not correlated with the age of the subjects, whereas others had observed an accumulation of CD8+ CD28-T cells in the elderly, including centenarians [12,13,14].
Positive_regulation (accumulation) of CD8 in T cells
7) Confidence 0.47 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.13 Pain Relevance 0.39
This increase of CD8+ CD28-cells, together with reduced circulating naive CD8+ T cells correlates with immunodeficiency during aging [15,16].
Positive_regulation (increase) of CD8 in T cells associated with aging and immunodeficiency
8) Confidence 0.47 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.09 Pain Relevance 0.30
Interestingly, the leishmanicidal treatment of the DCL patients not only reduced the parasite load but also led to an increase in CD8 during the healing process of the skin lesions of these DCL patients [11].
Positive_regulation (increase) of CD8 in skin associated with diffuse cutaneous leishmaniasis
9) Confidence 0.47 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.06 Pain Relevance 0.03
Since TLR2 signaling in CD8 enhanced proliferation and survival in vitro [19], we analyzed whether TLR2 stimulation of CD8 from DCL patients could also restore their functional capacity.
Positive_regulation (stimulation) of CD8 associated with diffuse cutaneous leishmaniasis
10) Confidence 0.47 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.16 Pain Relevance 0.18
We found that this preactivation could increase CD8 cytotoxicity against MOi.
Positive_regulation (increase) of CD8
11) Confidence 0.47 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.25 Pain Relevance 0
production in human NK cells [6], we therefore stimulated CD8 from DCL patients with LPG and also with Pam3Cys, a recognized specific TLR2 ligands (Figure 6A, B and C).
Positive_regulation (stimulated) of CD8 in NK cells associated with diffuse cutaneous leishmaniasis
12) Confidence 0.47 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.30 Pain Relevance 0
Further, morphine attenuated CD8+ T cell-mediated suppression of the HIV long-terminal repeat promoter activation.
Positive_regulation (activation) of CD8 in T cell associated with acquired immune deficiency syndrome or hiv infection and morphine
13) Confidence 0.46 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16000393 Disease Relevance 0.92 Pain Relevance 0.81
Examination of bronchoalveolar lavage fluid showed an elevated CD4/CD8 ratio.
Positive_regulation (elevated) of CD8
14) Confidence 0.45 Published 2007 Journal Clin Neurol Neurosurg Section Abstract Doc Link 17651894 Disease Relevance 0.53 Pain Relevance 0.12
The transient increase in CD4/CD8 ratio was likely due to the TCM intake.
Positive_regulation (increase) of CD8
15) Confidence 0.45 Published 2006 Journal Am. J. Chin. Med. Section Abstract Doc Link 16437735 Disease Relevance 0.47 Pain Relevance 0.12
Examination of immunological parameters revealed a transient decrease in CD25(+) peripheral blood lymphocytes and, in seven of eight patients, an increase in CD4(+):CD8(+) ratios at 2 weeks.
Positive_regulation (increase) of CD8 in lymphocytes
16) Confidence 0.45 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815786 Disease Relevance 0.85 Pain Relevance 0.09
In the control group which consisted of 23 persons who continued injecting drug use, only 3 (13%) out of the showed increase in the CD4+ lymphocyte percentage and CD4/CD8 lymphocyte ratio.
Positive_regulation (increase) of CD8 in lymphocyte
17) Confidence 0.45 Published 1996 Journal Pol Tyg Lek Section Abstract Doc Link 9273524 Disease Relevance 0.16 Pain Relevance 0.23
As a considerable number of AS patients tested seronegative for CMV, but showed an accumulation of CD8+ CD28- T cells in the peripheral blood, the two phenomena appear to be independent of each other in AS patients.


Positive_regulation (accumulation) of CD8 in blood associated with spinal inflammation and cytomegalovirus infection
18) Confidence 0.44 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 2.21 Pain Relevance 0.87
When pulsed with the EBNA258-266 peptide, autologous chondrocytes functioned as APCs and, specifically, induced interferon-gamma production in CD8+ T cells.
Positive_regulation (induced) of CD8 in chondrocytes
19) Confidence 0.44 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19479861 Disease Relevance 0.07 Pain Relevance 0
Induction of HIV-Specific CD8+ T-Cell Responses
Positive_regulation (Induction) of CD8 associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.97 Pain Relevance 0.30

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