INT183114

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 7.61
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SULF1) Golgi apparatus (SULF1) endoplasmic reticulum (SULF1)
plasma membrane (SULF1)
Anatomy Link Frequency
head 3
fibroblasts 2
neck 1
SULF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 121 98.16 Very High Very High Very High
Inflammation 11 71.52 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 616 100.00 Very High Very High Very High
Cancer 110 98.48 Very High Very High Very High
Pancreatitis 121 98.16 Very High Very High Very High
Malignant Neoplastic Disease 11 98.00 Very High Very High Very High
Metastasis 33 97.20 Very High Very High Very High
Ovarian Cancer 55 96.08 Very High Very High Very High
Skin Cancer 22 91.72 High High
INFLAMMATION 11 71.52 Quite High
Liver Cancer 11 65.92 Quite High
Disease 11 50.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hsulf-1 expression significantly attenuated FGF-2 (50 ng/ml) induced cell growth by around 50%, from +28.0 ± 3.8% in controls to +14.4 ± 1.0 % in Hsulf-1 clones (Figure 6).
Positive_regulation (induced) of Gene_expression (expression) of Hsulf-1
1) Confidence 0.48 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.39 Pain Relevance 0
Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer

Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding growth factor signaling.

Positive_regulation (Enhanced) of Gene_expression (levels) of Hsulf-1 in head associated with pancreatic cancer and skin cancer
2) Confidence 0.45 Published 2005 Journal Mol Cancer Section Title Doc Link PMC1087876 Disease Relevance 0.65 Pain Relevance 0
Thus, Hsulf-1 mRNA expression levels were increased 9.1-fold in primary pancreatic cancer, 4.5-fold in pancreatic cancer metastasis, and 3.4-fold in CP tissues compared to normal pancreatic tissues.
Positive_regulation (increased) of Gene_expression (expression) of Hsulf-1 mRNA associated with pancreatic cancer and metastasis
3) Confidence 0.45 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.45 Pain Relevance 0.31
Panc-1 pancreatic cancer cells were stably transfected with the Hsulf-1 plasmid and with the empty control vector using the lipofectamine reagent [7,8].
Positive_regulation (transfected) of Gene_expression (transfected) of Hsulf-1 associated with pancreatic cancer
4) Confidence 0.45 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.17 Pain Relevance 0
The observed increased levels of Hsulf-1 in pancreatic cancer tissues seem to be in contrast to the down-regulation of Hsulf-1 in HCC and ovarian tumors [11,12].
Positive_regulation (increased) of Gene_expression (levels) of Hsulf-1 associated with ovarian cancer and pancreatic cancer
5) Confidence 0.45 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.05 Pain Relevance 0.04
It has been hypothesized that enhanced expression of Hsulf-1 is related to c-myc amplification in HCCs [12].
Positive_regulation (enhanced) of Gene_expression (expression) of Hsulf-1
6) Confidence 0.45 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.27 Pain Relevance 0.03
Stable transfection of the Hsulf-1 negative Panc-1 pancreatic cancer cell line with a full length Hsulf-1 expression vector resulted in increased sulfatase activity and decreased cell-surface heparan-sulfate proteoglycan (HSPG) sulfation.
Positive_regulation (transfection) of Gene_expression (expression) of Hsulf-1 associated with pancreatic cancer
7) Confidence 0.45 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1087876 Disease Relevance 0.68 Pain Relevance 0
Pancreatic cancer samples expressed significantly (22.5-fold) increased Hsulf-1 mRNA levels compared to normal controls, and Hsulf-1 mRNA was localized in the cancer cells themselves as well as in peritumoral fibroblasts. 4 out of 8 examined pancreatic cancer cell lines expressed Hsulf-1, whereas its expression was below the level of detection in the other cell lines.
Positive_regulation (increased) of Gene_expression (expressed) of Hsulf-1 mRNA in fibroblasts associated with cancer and pancreatic cancer
8) Confidence 0.45 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1087876 Disease Relevance 0.73 Pain Relevance 0
The 2 control clones showed an average colony number of 223 as compared to 31 colonies for the Hsulf-1 transfected cells (Figure 5 B).


Positive_regulation (transfected) of Gene_expression (transfected) of Hsulf-1
9) Confidence 0.42 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.39 Pain Relevance 0
In contrast, control cells showed increased MAPK phosphorylation after FGF-2 stimulation, while this FGF-2 induced phosphorylation was markedly attenuated in Hsulf-1 transfected cells (Figure 7 B).
Positive_regulation (transfected) of Gene_expression (transfected) of Hsulf-1
10) Confidence 0.42 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.20 Pain Relevance 0
Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer

Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding growth factor signaling.

Positive_regulation (Enhanced) of in neck Gene_expression (levels) of Hsulf-1 in head associated with pancreatic cancer and skin cancer
11) Confidence 0.15 Published 2005 Journal Mol Cancer Section Title Doc Link PMC1087876 Disease Relevance 0.65 Pain Relevance 0

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