INT183119

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2005
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 70
Disease Relevance 46.71
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SULF1) Golgi apparatus (SULF1) endoplasmic reticulum (SULF1)
plasma membrane (SULF1)
Anatomy Link Frequency
fibroblasts 2
neck 1
liver 1
pancreas 1
smooth muscle cells 1
SULF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 770 100.00 Very High Very High Very High
Inflammation 70 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 3920 100.00 Very High Very High Very High
Pancreatitis 770 100.00 Very High Very High Very High
Cancer 700 99.24 Very High Very High Very High
Ovarian Cancer 350 99.16 Very High Very High Very High
Apoptosis 70 98.88 Very High Very High Very High
Malignant Neoplastic Disease 70 97.60 Very High Very High Very High
Liver Cancer 70 97.32 Very High Very High Very High
Metastasis 210 96.44 Very High Very High Very High
INFLAMMATION 70 96.04 Very High Very High Very High
Skin Cancer 140 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, it has been shown that Hsulf-1 expression enhances cisplatin-induced apoptosis in HCC cell lines [12].
Gene_expression (expression) of Hsulf-1 associated with apoptosis
1) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.59 Pain Relevance 0.05
Therefore, we further investigated whether over-expression of Hsulf-1 could modulate the function of these growth factors in pancreatic cancer cells.
Gene_expression (over) of Hsulf-1 associated with pancreatic cancer
2) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.44 Pain Relevance 0
The observation that Hsulf-1 expression does not interfere with HB-EGF signaling in pancreatic cancer cells is in contrast to recent studies in ovarian cancer cells [11], suggesting cell type specific differences.
Gene_expression (expression) of Hsulf-1 associated with ovarian cancer and pancreatic cancer
3) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.47 Pain Relevance 0
This analysis demonstrated that Hsulf-1 mRNA expression was weakly present in normal acinar cells, and at high levels in the endothelium and smooth muscle cells of blood vessels, as well as in fibroblasts and tubular complexes in CP tissues and additionally in the malignant cells in pancreatic cancer tissues.
Gene_expression (expression) of Hsulf-1 mRNA in smooth muscle cells associated with malignant neoplastic disease and pancreatic cancer
4) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.02 Pain Relevance 0.04
Nonetheless, FGF-2 still induced growth in Hsulf-1 expressing cells, but to a lesser extent compared with control cells.
Gene_expression (expressing) of Hsulf-1
5) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.53 Pain Relevance 0
In contrast, no difference between Hsulf-1 expressing and control cells was observed upon stimulation with HB-EGF – another heparin-binding growth factor- as well as EGF and IGF-1 suggesting that these growth factors and their receptors do not require sulfated HSPGs for effective signaling.
Gene_expression (expressing) of Hsulf-1
6) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.47 Pain Relevance 0
Since Hsulf-1 expression reduced FGF-2 but not EGF or HB-EGF induced cell proliferation, next we sought to investigate whether Hsulf-1 expression would influence FGF-2 and EGF/HB-EGF downstream signaling.
Spec (whether) Gene_expression (expression) of Hsulf-1
7) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.32 Pain Relevance 0
To identify the local expression pattern of Hsulf-1 in the normal pancreas, chronic pancreatitis and pancreatic cancer tissues, in situ hybridization analysis was carried out.
Gene_expression (expression) of Hsulf-1 in pancreas associated with pancreatic cancer and chronic pancreatitis
8) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.33 Pain Relevance 0.55
Next, the effects of Hsulf-1 expression on the growth of Panc-1 cells were assessed.
Gene_expression (expression) of Hsulf-1
9) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.15 Pain Relevance 0
This analysis revealed relatively high expression of Hsulf-1 mRNA in Su-8686 and moderate expression in T3M4, Colo-357, and BxPc-3 pancreatic cancer cell lines.
Gene_expression (expression) of Hsulf-1 mRNA associated with pancreatic cancer
10) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.00 Pain Relevance 0.28
Hsulf-1 expression in pancreatic cancer cell lines
Gene_expression (expression) of Hsulf-1 associated with pancreatic cancer
11) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.14 Pain Relevance 0.36
This analysis revealed a significant reduction in the invasiveness of FGF-2 exposed Hsulf-1 expressing cells compared to Hsulf-1 negative clones.
Gene_expression (expressing) of Hsulf-1
12) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.16 Pain Relevance 0
However, while in ovarian cancer markedly diminished levels were observed in approximately 75% of the cases [11], the percentage was much smaller in HCCs (30%) [12], suggesting that reduced Hsulf-1 expression is not universally observed in all tumor types.
Gene_expression (expression) of Hsulf-1 associated with cancer and ovarian cancer
13) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.21 Pain Relevance 0.03
Hsulf-1 expression significantly attenuated FGF-2 (50 ng/ml) induced cell growth by around 50%, from +28.0 ± 3.8% in controls to +14.4 ± 1.0 % in Hsulf-1 clones (Figure 6).
Gene_expression (expression) of Hsulf-1
14) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.39 Pain Relevance 0
Hsulf-1 expression in Panc-1 cells also partially blocked FGF-2 induced MAPK phosphorylation and invasion, further supporting the hypothesis that Hsulf-1 interferes with FGF-2 signaling in pancreatic cancer cells.
Gene_expression (expression) of Hsulf-1 associated with pancreatic cancer
15) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.35 Pain Relevance 0
To confirm this hypothesis, in situ hybridization was utilized to localize Hsulf-1 mRNA expression in normal, CP and pancreatic cancer tissues.
Gene_expression (expression) of Hsulf-1 mRNA associated with pancreatic cancer
16) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.00 Pain Relevance 0.04
In addition, Hsulf-1 mRNA expression was present in tubular complexes of chronic pancreatitis tissues (Figure 2 D).
Gene_expression (expression) of Hsulf-1 mRNA associated with chronic pancreatitis
17) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.21 Pain Relevance 0.47
Functional consequences of Hsulf-1 expression in Panc-1 pancreatic cancer cells
Gene_expression (expression) of Hsulf-1 associated with pancreatic cancer
18) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.10 Pain Relevance 0
In the other cell lines, Hsulf-1 expression was below the detection level (Figure 3 A).
Gene_expression (expression) of Hsulf-1
19) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.81 Pain Relevance 0.21
Hsulf-1 expression is down-regulated in ovarian cancers, and lost in a proportion of liver cancers [11,12].
Gene_expression (expression) of Hsulf-1 in liver associated with liver cancer and ovarian cancer
20) Confidence 0.75 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.71 Pain Relevance 0

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