INT183124

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.92
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SULF1) Golgi apparatus (SULF1) endoplasmic reticulum (SULF1)
plasma membrane (SULF1)
SULF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 66 100.00 Very High Very High Very High
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 336 100.00 Very High Very High Very High
Pancreatitis 66 100.00 Very High Very High Very High
Cancer 60 81.52 Quite High
Apoptosis 6 78.52 Quite High
Ovarian Cancer 30 72.68 Quite High
Metastasis 18 5.00 Very Low Very Low Very Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Skin Cancer 12 5.00 Very Low Very Low Very Low
Liver Cancer 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, the effects of Hsulf-1 expression on the growth of Panc-1 cells were assessed.
Regulation (effects) of Gene_expression (expression) of Hsulf-1
1) Confidence 0.59 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.15 Pain Relevance 0
Since Hsulf-1 expression reduced FGF-2 but not EGF or HB-EGF induced cell proliferation, next we sought to investigate whether Hsulf-1 expression would influence FGF-2 and EGF/HB-EGF downstream signaling.
Spec (whether) Regulation (influence) of Spec (whether) Gene_expression (expression) of Hsulf-1
2) Confidence 0.43 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.32 Pain Relevance 0
Functional consequences of Hsulf-1 expression in Panc-1 pancreatic cancer cells
Regulation (consequences) of Gene_expression (expression) of Hsulf-1 associated with pancreatic cancer
3) Confidence 0.43 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.10 Pain Relevance 0
In conclusion, Hsulf-1 is up-regulated in pancreatic cancer and chronic pancreatitis compared to normal pancreatic tissues, mainly due to over-expression in the desmoplastic and cancerous tissue elements.
Regulation (regulated) of Gene_expression (expression) of Hsulf-1 associated with pancreatic cancer and chronic pancreatitis
4) Confidence 0.43 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.72 Pain Relevance 0.10
Therefore, we further investigated whether over-expression of Hsulf-1 could modulate the function of these growth factors in pancreatic cancer cells.
Regulation (modulate) of Gene_expression (over) of Hsulf-1 associated with pancreatic cancer
5) Confidence 0.43 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.44 Pain Relevance 0
Effects of Hsulf-1 expression on chemosensitivity
Regulation (Effects) of Gene_expression (expression) of Hsulf-1
6) Confidence 0.26 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.18 Pain Relevance 0

General Comments

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