INT183129

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 5.19
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SULF1) Golgi apparatus (SULF1) endoplasmic reticulum (SULF1)
plasma membrane (SULF1)
Anatomy Link Frequency
liver 6
SULF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 87.60 High High
Chronic pancreatitis 77 46.72 Quite Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 35 100.00 Very High Very High Very High
Pancreatic Cancer 392 99.24 Very High Very High Very High
Liver Cancer 7 99.20 Very High Very High Very High
Cancer 70 98.56 Very High Very High Very High
Skin Cancer 14 90.24 High High
Disease 7 88.44 High High
INFLAMMATION 7 87.60 High High
Malignant Neoplastic Disease 7 84.76 Quite High
Metastasis 21 65.64 Quite High
Pancreatitis 77 46.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hsulf-1 expression in Panc-1 cells also partially blocked FGF-2 induced MAPK phosphorylation and invasion, further supporting the hypothesis that Hsulf-1 interferes with FGF-2 signaling in pancreatic cancer cells.
Negative_regulation (blocked) of Gene_expression (expression) of Hsulf-1 associated with pancreatic cancer
1) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.41 Pain Relevance 0
However, while in ovarian cancer markedly diminished levels were observed in approximately 75% of the cases [11], the percentage was much smaller in HCCs (30%) [12], suggesting that reduced Hsulf-1 expression is not universally observed in all tumor types.
Negative_regulation (reduced) of Gene_expression (expression) of Hsulf-1 associated with cancer and ovarian cancer
2) Confidence 0.56 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.21 Pain Relevance 0.03
Hsulf-1 expression is down-regulated in ovarian cancers, and lost in a proportion of liver cancers [11,12].
Negative_regulation (lost) of Gene_expression (expression) of Hsulf-1 in liver associated with liver cancer and ovarian cancer
3) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.77 Pain Relevance 0
Hsulf-1 expression is down-regulated in ovarian cancers, and lost in a proportion of liver cancers [11,12].
Negative_regulation (down) of Gene_expression (expression) of Hsulf-1 in liver associated with liver cancer and ovarian cancer
4) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.71 Pain Relevance 0
Hsulf-1 expression is down-regulated in ovarian cancers, and lost in a proportion of liver cancers [11,12].
Negative_regulation (regulated) of Gene_expression (expression) of Hsulf-1 in liver associated with liver cancer and ovarian cancer
5) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.71 Pain Relevance 0
To confirm this hypothesis, in situ hybridization was utilized to localize Hsulf-1 mRNA expression in normal, CP and pancreatic cancer tissues.
Negative_regulation (localize) of Gene_expression (expression) of Hsulf-1 mRNA associated with pancreatic cancer
6) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 1.00 Pain Relevance 0.04
Hsulf-1 expression significantly attenuated FGF-2 (50 ng/ml) induced cell growth by around 50%, from +28.0 ± 3.8% in controls to +14.4 ± 1.0 % in Hsulf-1 clones (Figure 6).
Negative_regulation (attenuated) of Gene_expression (expression) of Hsulf-1
7) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1087876 Disease Relevance 0.39 Pain Relevance 0

General Comments

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