INT183147

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.67
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MEFV) cytoskeleton (MEFV) nucleus (MEFV)
intracellular (MEFV) cytoplasm (MEFV)
Anatomy Link Frequency
plasma 2
monocyte 2
HeLa 2
MEFV (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 194 100.00 Very High Very High Very High
chemokine 24 98.84 Very High Very High Very High
cytokine 24 94.92 High High
Inflammation 173 94.72 High High
Arthritis 10 89.64 High High
Pain 34 89.08 High High
abdominal pain 8 87.24 High High
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 8 5.00 Very Low Very Low Very Low
Catecholamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 262 100.00 Very High Very High Very High
Fibromyalgia 194 100.00 Very High Very High Very High
Familial Mediterranean Fever 174 100.00 Very High Very High Very High
INFLAMMATION 176 94.72 High High
Amyloidosis 6 90.56 High High
Arthritis 10 89.64 High High
Pain 35 89.08 High High
Abdominal Pain 8 87.24 High High
Disease 152 83.72 Quite High
Injury 7 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 2, MCP-1, IP-10 and eotaxin plasma levels were elevated, on average, for all FMS patients vs. unrelated controls, except those with the rare alleles for the MEFV gene, who were empirically intermediate, but cannot be statistically distinguished from either controls or other FMS patients.
Positive_regulation (elevated) of Gene_expression (gene) of MEFV in plasma associated with fibrositis
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.63 Pain Relevance 0.49
, a chemokine involved in monocyte migration and activation [45], were elevated in subjects with the rare MEFV alleles compared to other FMS patients (p?
Positive_regulation (elevated) of Gene_expression (alleles) of MEFV in monocyte associated with chemokine and fibrositis
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.71 Pain Relevance 0.59
415 of 1100 patients suspected as FMF were diagnosed as having FMF according to Yalc?
Positive_regulation (diagnosed) of Gene_expression (having) of FMF associated with familial mediterranean fever
3) Confidence 0.42 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2825617 Disease Relevance 1.08 Pain Relevance 0.22
415 of 1100 patients suspected as FMF were diagnosed as having FMF according to Yalc?
Positive_regulation (according) of Gene_expression (having) of FMF associated with familial mediterranean fever
4) Confidence 0.42 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2825617 Disease Relevance 1.08 Pain Relevance 0.22
Indeed, in earlier studies, we demonstrated that, in HeLa cells (which do not express PSTPIP1) co-transfection of pyrin and ASC promotes ASC speck formation [32].
Positive_regulation (promotes) of Gene_expression (transfection) of pyrin in HeLa
5) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0.17 Pain Relevance 0.04
When ASC specks form in cells transfected with ASC and pyrin, both proteins are always co-localized in the specks (Figure 9A–D).
Positive_regulation (transfected) of Gene_expression (transfected) of pyrin
6) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702820 Disease Relevance 0 Pain Relevance 0
There was much debate about the value of suggestions that inflammation was a “natural” feature of childbirth, some physicians arguing that it offered the obvious explanation for conditions such as puerperal fever, others maintaining that it did not explain why all women did not suffer from such fevers.70 In attempting to understand how puerperal fever could arise in some, but not all, women, physicians took the view that, whilst all parturient women had a natural tendency towards fever, only those in whom there were predisposing factors were at serious risk.71
Positive_regulation (how) of Neg (not) Gene_expression (arise) of puerperal fever associated with inflammation and fever
7) Confidence 0.06 Published 2005 Journal Medical History Section Body Doc Link PMC1088248 Disease Relevance 0.99 Pain Relevance 0.17

General Comments

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