INT183164

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.69
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Macrophages 2
B cells 2
CD86 1
Cd80 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 47 90.36 High High
chemokine 3 89.20 High High
adenocard 36 88.44 High High
cytokine 40 82.48 Quite High
Deep tissue 2 80.36 Quite High
Inflammation 77 74.92 Quite High
agonist 21 30.00 Quite Low
anesthesia 7 27.40 Quite Low
Neuritis 24 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 66 99.36 Very High Very High Very High
Cancer 183 98.96 Very High Very High Very High
Targeted Disruption 25 86.16 High High
Hypersensitivity 2 81.76 Quite High
Adhesions 4 80.12 Quite High
Malignant Neoplastic Disease 3 79.84 Quite High
Pleurisy 1 76.20 Quite High
INFLAMMATION 67 74.92 Quite High
Lung Injury 35 67.84 Quite High
Toxicity 7 62.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Regulation (evaluated) of CD80 in B cells
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
As B cells are being activated, they up-regulate surface expression of co-stimulatory molecules such as CD80 and CD86.
Regulation (regulate) of CD80 in B cells
2) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
[33], granulocyte-macrophage colony-stimulating factor [34], and induced down-regulation of cosignaling molecules (CD80) [35].
Regulation (regulation) of CD80 in macrophage
3) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 1.30 Pain Relevance 0.22
Macrophages of apoE-deficient mice stimulated by exogenous antigen are more effective in the upregulating of main histocompatibility complex (MHC) class II molecules and costimulatory molecules like CD40 and CD80, with increased IFN-?
Regulation (upregulating) of CD80 in Macrophages
4) Confidence 0.24 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.32 Pain Relevance 0.07
Furthermore, up-regulated levels of the maturation markers CD80 and CD86 were found in CD11c+ subpopulation recovered from HIFU-treated tumors (Figure 6B, D, and 6E), indicating HIFU-treatment induced infiltrated DCs towards a mature phenotype.
Regulation (regulated) of CD80 in CD86 associated with cancer
5) Confidence 0.21 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.99 Pain Relevance 0
Both CD80 and CD40 were up-regulated in the presence of LPS, but addition of SGE did not alter this expression (Figure 1A).
Regulation (regulated) of CD80
6) Confidence 0.04 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0 Pain Relevance 0.10

General Comments

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