INT183167

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.37
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Anatomy Link Frequency
granulocytes 4
macrophages 2
cytotoxic T lymphocyte 2
Adora2a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 220 100.00 Very High Very High Very High
agonist 68 100.00 Very High Very High Very High
Morphine 172 99.80 Very High Very High Very High
Inflammation 184 99.56 Very High Very High Very High
Physical dependence 10 97.96 Very High Very High Very High
antagonist 56 96.72 Very High Very High Very High
withdrawal 9 95.30 Very High Very High Very High
Central nervous system 11 95.12 Very High Very High Very High
Opioid 28 95.08 Very High Very High Very High
chemokine 6 70.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 138 99.56 Very High Very High Very High
Pneumonia 66 99.24 Very High Very High Very High
Drug Dependence 12 97.96 Very High Very High Very High
Cancer 4 96.80 Very High Very High Very High
Necrosis 4 96.56 Very High Very High Very High
Sprains And Strains 84 96.00 Very High Very High Very High
Opiate Addiction 8 95.30 Very High Very High Very High
Vibrio Infection 2 89.60 High High
Adult Respiratory Distress Syndrome 160 72.72 Quite High
Increased Venous Pressure Under Development 8 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When compared to the several-fold increase in A2AR mRNA expression levels in inflammatory granulocytes from mice exposed to 21% oxygen, these levels were up-regulated to a much lesser extent in mice breathing 100% oxygen.
Positive_regulation (increase) of Gene_expression (expression) of A2AR mRNA in granulocytes associated with inflammation
1) Confidence 0.70 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.22 Pain Relevance 0.21
Results of parallel assays confirmed increased expression of A2AR on activated granulocytes, since CGS21680 inhibited the functional response of in vivo-activated granulocytes (i.e., as evidenced by the production of tissue-damaging reactive oxygen species) much more strongly than in naïve cells (Figure 4A, right graph).
Positive_regulation (increased) of Gene_expression (expression) of A2AR in granulocytes
2) Confidence 0.70 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0 Pain Relevance 0.16
Severe symptoms of opioid withdrawal observed in SWR/J mice were associated with strong transcriptional activation of cytotoxic T lymphocyte-associated protein 2 (Ctla2a) and methionine adenosyltransferase II (Mat2a) genes after acute administration of morphine, whereas changes in gene expression of adenosine A2a receptor (Adora2a) were negatively related to the level of morphine physical dependence across the four inbred mouse strains (Figure 7).
Positive_regulation (changes) of Gene_expression (expression) of Adora2a in cytotoxic T lymphocyte associated with adenocard, physical dependence, sprains and strains, withdrawal, opioid and morphine
3) Confidence 0.46 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.67 Pain Relevance 1.31
In macrophages, A2A expression is increased more than 100-fold upon LPS exposure [45].
Positive_regulation (increased) of Gene_expression (expression) of A2A in macrophages
4) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.46 Pain Relevance 0.19
In addition, the same A2A agonist reduced LPS-induced microvascular permeability and secretion of interleukin-6, tumor necrosis factor-?
Positive_regulation (same) of Gene_expression (agonist) of A2A associated with necrosis, cancer and agonist
5) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.03 Pain Relevance 0.44

General Comments

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