INT183182

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FGFR2) Golgi apparatus (FGFR2) cytoplasmic membrane-bounded vesicle (FGFR2)
plasma membrane (FGFR2) nucleus (FGFR2) cell-cell signaling (FGFR2)
Anatomy Link Frequency
cartilage 1
FGFR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 3 98.98 Very High Very High Very High
antidepressant 4 98.56 Very High Very High Very High
depression 23 96.48 Very High Very High Very High
Nicotine 1 86.00 High High
fluoxetine 2 68.00 Quite High
Serotonin 1 64.88 Quite High
Hippocampus 3 57.68 Quite High
imagery 2 52.20 Quite High
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 28 96.48 Very High Very High Very High
Focal Cartilage Defect 1 94.96 High High
Cognitive Disorder 2 89.04 High High
Injury 6 86.80 High High
Mental Disorders 2 86.08 High High
Manic Depressive Disorder 9 85.00 Quite High
Schizophrenia 2 76.40 Quite High
Affective Disorder 7 51.44 Quite High
Wound Healing 16 50.00 Quite Low
Psychosis 1 32.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A history of antidepressant treatment with SSRIs in the depressed subjects seemed to mitigate this decrease in FGFs and FGF receptors, especially for FGF2, FGFR2 and FGFR3.
Negative_regulation (decrease) of FGFR2 associated with antidepressant and ssri
1) Confidence 0.29 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 1.07 Pain Relevance 0.84
Cell proliferation and expression of KGF and KGFR in tracheal cartilage after surgery
Negative_regulation (proliferation) of KGFR in cartilage
2) Confidence 0.21 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2896696 Disease Relevance 0.18 Pain Relevance 0

General Comments

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