INT183184

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.32
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (NUDT6) nucleus (NUDT6) cellular_component (NUDT6)
biological_process (NUDT6) cytoplasm (NUDT6)
Anatomy Link Frequency
fibroblast 1
NUDT6 (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 3 98.98 Very High Very High Very High
antidepressant 4 98.56 Very High Very High Very High
depression 23 94.84 High High
metalloproteinase 2 91.40 High High
Nicotine 1 82.96 Quite High
Inflammation 2 80.64 Quite High
fluoxetine 2 66.76 Quite High
Serotonin 1 64.88 Quite High
Hippocampus 3 57.68 Quite High
imagery 2 52.20 Quite High
Disease Link Frequency Relevance Heat
Depression 28 94.84 High High
Mental Disorders 2 86.08 High High
Cognitive Disorder 2 86.00 High High
Manic Depressive Disorder 9 85.00 Quite High
Apoptosis 8 82.96 Quite High
INFLAMMATION 2 80.64 Quite High
Schizophrenia 2 73.36 Quite High
Necrosis 4 51.84 Quite High
Cancer 2 51.48 Quite High
Affective Disorder 7 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A history of antidepressant treatment with SSRIs in the depressed subjects seemed to mitigate this decrease in FGFs and FGF receptors, especially for FGF2, FGFR2 and FGFR3.
Negative_regulation (decrease) of FGF associated with antidepressant and ssri
1) Confidence 0.11 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 1.05 Pain Relevance 0.83
Two genes related to fibroblast growth factor (FGF) showed significant differences in senescent cells (FGF % was downregulated, and FGF-receptor 2 was up-regulated).
Negative_regulation (downregulated) of FGF in fibroblast
2) Confidence 0.08 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.27 Pain Relevance 0.09
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of FGF
3) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0

General Comments

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