INT183206

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Context Info
Confidence 0.13
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.17
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (UTS2R) plasma membrane (UTS2R) signal transducer activity (UTS2R)
UTS2R (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 53 95.52 Very High Very High Very High
Neurotransmitter 7 78.76 Quite High
adenocard 1 36.92 Quite Low
cytokine 86 5.00 Very Low Very Low Very Low
imagery 54 5.00 Very Low Very Low Very Low
Pain 34 5.00 Very Low Very Low Very Low
Inflammation 30 5.00 Very Low Very Low Very Low
positron emission tomography 24 5.00 Very Low Very Low Very Low
Nerve growth factor 20 5.00 Very Low Very Low Very Low
Peripheral nervous system 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Meningioma 2 96.36 Very High Very High Very High
Cancer 432 96.04 Very High Very High Very High
Repression 3 95.44 Very High Very High Very High
Immunotherapy Of Cancer 5 94.76 High High
Cold Sores 734 77.40 Quite High
Adhesions 4 74.84 Quite High
Nervous System Malformation 9 69.04 Quite High
Toxicity 32 59.24 Quite High
Hepatocellular Cancer 9 56.24 Quite High
Targeted Disruption 2 53.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-UTR of an mRNA can have a major influence on developmental and tissue-specific regulation of gene expression.
Regulation (regulation) of UTR
1) Confidence 0.13 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1088970 Disease Relevance 0 Pain Relevance 0
Through synergistic effects of various regulatory elements in the promoter 5’-UTR or 3’UTR stringent regulation of viral gene expression and viral replication will be possible to develop a highly effective and tumour-specific virotherapy for cancer treatment.
Spec (possible) Regulation (regulation) of UTR associated with cancer and immunotherapy of cancer
2) Confidence 0.10 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.14 Pain Relevance 0
Through synergistic effects of various regulatory elements in the promoter 5’-UTR or 3’UTR stringent regulation of viral gene expression and viral replication will be possible to develop a highly effective and tumour-specific virotherapy for cancer treatment.
Spec (possible) Regulation (regulation) of UTR associated with cancer and immunotherapy of cancer
3) Confidence 0.10 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.09 Pain Relevance 0
The strength of purifying selection acting on promoter, UTR, nonrepetitive intronic and nonrepetitive intergenic (referred to as intronic and intergenic, respectively, later on) bricks was higher than at synonymous and repetitive sites, suggesting that nonrepetitive and noncoding amniota (and higher level) bricks are indicative of negative selection, and thus likely to be associated with noncoding functional elements.
Regulation (acting) of UTR
4) Confidence 0.10 Published 2010 Journal Molecular Biology and Evolution Section Body Doc Link PMC2872621 Disease Relevance 0 Pain Relevance 0
-UTR of the AGTR1 gene (rs5186) was found to affect the miRNA-155 recognition site and changes its silencing effects [118].
Regulation (changes) of UTR
5) Confidence 0.08 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2235910 Disease Relevance 0.48 Pain Relevance 0
The importance of 3'-UTRs in regulating gene expression is also underlined by the finding that mutations affecting the 3'-UTR can lead to serious pathologies [35,36].
Regulation (affecting) of UTR
6) Confidence 0.08 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.07 Pain Relevance 0.12
-catenin signaling via directly targeting the 3'UTR of ?
Regulation (targeting) of UTR
7) Confidence 0.02 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.40 Pain Relevance 0

General Comments

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