INT183212

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.57
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
spinal cord 2
brain 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 307 100.00 Very High Very High Very High
Spinal cord 89 99.68 Very High Very High Very High
depression 90 98.92 Very High Very High Very High
Hippocampus 41 91.48 High High
ischemia 67 87.08 High High
Desipramine 4 83.76 Quite High
Sciatic nerve 68 81.64 Quite High
Serotonin 15 80.64 Quite High
Neurotransmitter 12 74.24 Quite High
antagonist 43 72.88 Quite High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 37 99.56 Very High Very High Very High
Depression 101 98.92 Very High Very High Very High
Stress 30 91.96 High High
Shock 4 89.04 High High
Cv General 4 Under Development 59 87.08 High High
Neurodegenerative Disease 8 80.88 Quite High
Weight Gain 2 71.04 Quite High
Hyperphagia 3 69.84 Quite High
Aggression 2 69.16 Quite High
Targeted Disruption 37 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study using different 5-HT enhancing ligands indicated that an increase in 5-HT, induced a ligand dependent and region specific modulation of BDNF mRNA levels in rat brain [336].
Positive_regulation (induced) of Regulation (modulation) of BDNF mRNA in brain associated with bdmf
1) Confidence 0.45 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.37 Pain Relevance 0.75
Upregulation of BDNF immunoreactivity in the spinal cord and DRG on the conditioning lesion side
Positive_regulation (Upregulation) of Regulation (immunoreactivity) of BDNF in spinal cord associated with bdmf and spinal cord
2) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.19 Pain Relevance 1.16
Furthermore, in patients with major depression, serum BDNF levels were decreased, while hippocampal BDNF immunoreactivity was increased in post-mortem tissues from subjects treated with anti-depressants [22].
Positive_regulation (increased) of Regulation (immunoreactivity) of BDNF associated with depression and bdmf
3) Confidence 0.29 Published 2005 Journal Ann Gen Psychiatry Section Body Doc Link PMC1090442 Disease Relevance 0.72 Pain Relevance 0.79
The early elevation of pCREB levels by EDC, was followed by elevation of its transcriptional target, BDNF at latter time points (6h and 1d reperfusion) in the hippocampal CA1 region.
Positive_regulation (elevation) of Regulation (target) of BDNF associated with bdmf
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.29 Pain Relevance 0.44

General Comments

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