INT18322

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2011
Negated 4
Speculated 1
Reported most in Abstract
Documents 132
Total Number 138
Disease Relevance 88.49
Pain Relevance 22.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
blood 11
plasma 10
brain 3
body 3
pancreas 3
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 37 100.00 Very High Very High Very High
Morphine 24 99.98 Very High Very High Very High
Inflammatory mediators 12 99.84 Very High Very High Very High
Paracetamol 53 99.82 Very High Very High Very High
tolerance 403 99.78 Very High Very High Very High
Intracerebroventricular 49 99.70 Very High Very High Very High
electroacupuncture 164 99.56 Very High Very High Very High
antagonist 104 99.46 Very High Very High Very High
agonist 308 98.98 Very High Very High Very High
substance P 7 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 1671 100.00 Very High Very High Very High
Insulin Resistance 1006 100.00 Very High Very High Very High
Stress 361 100.00 Very High Very High Very High
Hyperinsulinism 198 100.00 Very High Very High Very High
Weight Gain 80 100.00 Very High Very High Very High
Hyperglycemia 293 99.98 Very High Very High Very High
Acid Base Imbalance 18 99.96 Very High Very High Very High
Acidosis 18 99.90 Very High Very High Very High
Diabetes Mellitus 2342 99.88 Very High Very High Very High
Impaired Glucose Tolerance 314 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of insulin (1 U/kg) was markedly reduced by glucose (2 g/kg, i.v.), which can directly nourish the brain, but not by fructose (2 g/kg, i.v.), which cannot be used by the brain.
Negative_regulation (reduced) of insulin in brain
1) Confidence 0.58 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215646 Disease Relevance 0 Pain Relevance 0.39
Nortryptiline significantly increased glucose levels and reduced insulin levels in all animals.
Negative_regulation (reduced) of insulin
2) Confidence 0.58 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10454053 Disease Relevance 0.48 Pain Relevance 0.43
Insulin levels in ob/ob mice treated with clonidine were significantly reduced, while compound A raised insulin levels threefold and blocked the effects of clonidine when co-administered to the same animals.
Negative_regulation (reduced) of Insulin associated with obesity and clonidine
3) Confidence 0.57 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.88 Pain Relevance 0.80
Differential sensitivity to alpha 2-agonist in these genetically obese mice, ob/ob, was demonstrated by decreased insulin levels due to clonidine administration.
Negative_regulation (decreased) of insulin associated with obesity, agonist and clonidine
4) Confidence 0.57 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.81 Pain Relevance 0.64
Clonidine-induced hyperglycemia in lean littermates was not accompanied by a decrease in insulin levels, while a small but significant increase in insulin levels was observed by compound A administration.
Negative_regulation (decrease) of insulin associated with hyperglycemia and clonidine
5) Confidence 0.57 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.90 Pain Relevance 0.84
The effect of insulin was reduced by glucose (2 g/kg, i.v.) which can directly nourish the brain, but not by fructose (2 g/kg, i.v.) which cannot be utilized by the brain.
Neg (not) Negative_regulation (reduced) of insulin in brain
6) Confidence 0.55 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10193660 Disease Relevance 0 Pain Relevance 0.25
Morphine significantly lowered blood insulin in A/J mice, but effects in C57BL/6J mice were not significant.
Negative_regulation (lowered) of insulin in blood associated with morphine
7) Confidence 0.51 Published 1989 Journal Metab. Clin. Exp. Section Abstract Doc Link 2645504 Disease Relevance 0.51 Pain Relevance 0.71
Insulin levels were also unaffected by treatment but final corticosterone concentrations were consistently higher in fluoxetine-treated mice and lower in RU-486-treated mice.
Neg (unaffected) Negative_regulation (unaffected) of Insulin associated with fluoxetine
8) Confidence 0.43 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2124625 Disease Relevance 0.68 Pain Relevance 0.65
In contrast, morphine attenuated blood glucose and insulin during stress in C57BL/6J ob/ob but did not significantly affect either glucose or insulin during stress in lean C57BL/6J or A/J mice.
Negative_regulation (attenuated) of insulin in blood associated with stress and morphine
9) Confidence 0.43 Published 1989 Journal Metab. Clin. Exp. Section Abstract Doc Link 2645504 Disease Relevance 0.52 Pain Relevance 0.70
These results suggest that the central action of insulin is dependent not only on hypoglycaemia produced by it, but may be due also to its direct action on the central structures and an indirect action mediated by its effect on other neurotransmitter systems.
Negative_regulation (dependent) of insulin associated with hypoglycemia and neurotransmitter
10) Confidence 0.43 Published 1987 Journal Acta Physiol Pol Section Abstract Doc Link 3331234 Disease Relevance 0.34 Pain Relevance 0.68
In addition, insulin levels were low and unaffected by anesthesia.
Neg (unaffected) Negative_regulation (unaffected) of insulin
11) Confidence 0.42 Published 2005 Journal J. Nucl. Med. Section Body Doc Link 16157537 Disease Relevance 0 Pain Relevance 0
These observations suggest that the alpha 2-antagonist studied, increased plasma insulin levels with an accompanying reduction in blood glucose and an improvement in glucose tolerance in a genetic model of insulin resistance.
Negative_regulation (reduction) of insulin in blood associated with antagonist, tolerance, insulin resistance and impaired glucose tolerance
12) Confidence 0.42 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.89 Pain Relevance 0.87
The selective alpha 2-adrenoceptor agonist clonidine (0.05-50 nmol/kg) was found to markedly inhibit the insulin secretory response to both glucose and the cholinergic agonist carbachol.
Negative_regulation (inhibit) of insulin associated with agonist and clonidine
13) Confidence 0.41 Published 1986 Journal Pancreas Section Abstract Doc Link 2882501 Disease Relevance 0 Pain Relevance 0.32
It is concluded that alpha 1- and alpha 2-adrenoceptor blockade is followed by enhancement of basal plasma insulin levels in the mouse, whereas alpha 2-adrenoceptor stimulation but not alpha 1-adrenoceptor stimulation impairs the insulin secretory response to glucose and carbachol.
Negative_regulation (impairs) of insulin in plasma
14) Confidence 0.41 Published 1986 Journal Pancreas Section Abstract Doc Link 2882501 Disease Relevance 0 Pain Relevance 0.26
The presence of glybenclamide blocked the previously observed inhibitory effect of insulin (0.3 IU/ml) on the firing rate in warm-sensitive POA/AH neurons (Fig. 4D and E).
Negative_regulation (effect) of insulin in neurons
15) Confidence 0.38 Published 2010 Journal Diabetes Section Body Doc Link PMC2797943 Disease Relevance 0.33 Pain Relevance 0.03
While morphine produced significant increases in serum glucose in albino mice, morphine lowered blood insulin in both C57BL/6J ob/ob and C57BL/6J+/?
Negative_regulation (lowered) of insulin in blood associated with morphine
16) Confidence 0.37 Published 1989 Journal Metab. Clin. Exp. Section Abstract Doc Link 2645504 Disease Relevance 0.50 Pain Relevance 0.70
However, similar change was obtained at 21 days later of insulin injection in wild-type mice, showing that decrease of insulin action was more markedly in opioid mu-receptor knockout mice.
Negative_regulation (decrease) of insulin associated with targeted disruption and opioid
17) Confidence 0.37 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12614914 Disease Relevance 0.68 Pain Relevance 0.64
In type 1 diabetes, T cell-mediated death of pancreatic beta cells produces insulin deficiency.
Negative_regulation (deficiency) of insulin in pancreatic beta cells associated with diabetes mellitus and death
18) Confidence 0.37 Published 2006 Journal Cell Section Abstract Doc Link 17174891 Disease Relevance 1.01 Pain Relevance 0.13
Delivering the neuropeptide substance P by intra-arterial injection into the NOD pancreas reverses abnormal insulin resistance, insulitis, and diabetes for weeks.
Negative_regulation (reverses) of insulin in pancreas associated with diabetes mellitus, neuropeptide, insulin resistance and substance p
19) Confidence 0.36 Published 2006 Journal Cell Section Abstract Doc Link 17174891 Disease Relevance 1.34 Pain Relevance 0.22
Insulin resistance and beta cell stress of prediabetic NOD mice are prevented when TRPV1(+) neurons are eliminated.
Negative_regulation (prevented) of Insulin in neurons associated with stress and insulin resistance
20) Confidence 0.36 Published 2006 Journal Cell Section Abstract Doc Link 17174891 Disease Relevance 1.37 Pain Relevance 0.21

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