INT18323

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2011
Negated 1
Speculated 4
Reported most in Abstract
Documents 122
Total Number 129
Disease Relevance 45.74
Pain Relevance 23.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
blood 8
pancreatic islets 8
pancreatic beta cells 6
beta cells 6
liver 5
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 281 100.00 Very High Very High Very High
Clonidine 123 100.00 Very High Very High Very High
Neuropeptide 26 100.00 Very High Very High Very High
Enkephalin 30 99.98 Very High Very High Very High
tolerance 463 99.96 Very High Very High Very High
antagonist 262 99.96 Very High Very High Very High
narcan 18 99.84 Very High Very High Very High
Somatostatin 226 99.80 Very High Very High Very High
Neurotransmitter 19 99.80 Very High Very High Very High
Endogenous opioid 2 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Insulin Resistance 536 100.00 Very High Very High Very High
Impaired Glucose Tolerance 440 100.00 Very High Very High Very High
Hyperinsulinism 312 100.00 Very High Very High Very High
Diabetes Mellitus 2081 99.96 Very High Very High Very High
Hyperglycemia 322 99.92 Very High Very High Very High
Persistent Hyperinsulinemia Hypoglycemia Of Infancy 6 99.92 Very High Very High Very High
Bordatella Infection 40 99.86 Very High Very High Very High
Stress 167 99.82 Very High Very High Very High
Birth Weight 1 99.74 Very High Very High Very High
Targeted Disruption 1018 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucose inhibited insulin release also after activation of the alpha 2-adrenoceptors with B-HT 933, whereas blocking of these receptors with idazoxan removed glucose inhibition in the presence of clonidine.
Negative_regulation (inhibited) of Localization (release) of insulin associated with clonidine
1) Confidence 0.58 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 2876704 Disease Relevance 0 Pain Relevance 0.19
In contrast, deriglidole was approximately 100-fold more potent than SL 86.0714 in reversing the inhibition of insulin release caused by the activation of alpha 2-adrenoceptors with clonidine.
Negative_regulation (inhibition) of Localization (release) of insulin associated with clonidine
2) Confidence 0.58 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.13
SL 86.0714 and deriglidole were also equally effective in inhibiting 86Rb efflux from islets perifused with a low-glucose medium, and in reversing the inhibition of glucose-induced insulin release caused by the opening of ATP-sensitive K+ channels with diazoxide.
Negative_regulation (inhibition) of Localization (release) of insulin
3) Confidence 0.58 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7828647 Disease Relevance 0 Pain Relevance 0.12
BACKGROUND: Volatile anesthetics impair insulin secretion and glucose utilization; however, the precise mechanism of action that underlies these effects is unknown.
Negative_regulation (impair) of Localization (secretion) of insulin
4) Confidence 0.57 Published 2009 Journal Anesthesiology Section Abstract Doc Link 19809283 Disease Relevance 0.07 Pain Relevance 0.32
Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.
Negative_regulation (Inhibition) of Localization (release) of insulin
5) Confidence 0.57 Published 1988 Journal J. Biol. Chem. Section Title Doc Link 2892833 Disease Relevance 0.09 Pain Relevance 0.47
Addition of 2 microM clonidine promptly inhibited glucose-stimulated insulin release, an effect accompanied by a lowering in both membrane potential and [Ca2+]i.
Negative_regulation (inhibited) of Localization (release) of insulin associated with clonidine
6) Confidence 0.57 Published 1988 Journal J. Biol. Chem. Section Abstract Doc Link 2892833 Disease Relevance 0.10 Pain Relevance 0.43
The influence of sodium omission on alpha 2-adrenergic inhibition of insulin release by mouse islets.
Negative_regulation (inhibition) of Localization (release) of insulin
7) Confidence 0.56 Published 1990 Journal Life Sci. Section Title Doc Link 1975083 Disease Relevance 0 Pain Relevance 0.24
The mechanisms by which activation of alpha 2-adrenoceptors inhibits insulin release are still incompletely understood.
Negative_regulation (inhibits) of Localization (release) of insulin
8) Confidence 0.56 Published 1990 Journal Life Sci. Section Abstract Doc Link 1975083 Disease Relevance 0 Pain Relevance 0.20
Stimulation of alpha-adrenoceptors is known to inhibit insulin secretion under a variety of conditions.
Negative_regulation (inhibit) of Localization (secretion) of insulin
9) Confidence 0.56 Published 1986 Journal Pancreas Section Abstract Doc Link 2882501 Disease Relevance 0 Pain Relevance 0.25
This inhibition of insulin secretion was counteracted by the alpha 2-adrenoceptor antagonist yohimbine (2.6 mumol/kg), but not by the alpha 1-adrenoceptor antagonist prazosin (2.6 mumol/kg).
Negative_regulation (inhibition) of Localization (secretion) of insulin associated with antagonist
10) Confidence 0.56 Published 1986 Journal Pancreas Section Abstract Doc Link 2882501 Disease Relevance 0 Pain Relevance 0.33
Sulfonylureas stimulate insulin secretion by blocking ATP-sensitive K+ channels (K+-ATP channels) of the beta-cell membrane, thereby causing depolarization, Ca2+ influx, and rise in cytoplasmic Ca2+ concentration ([Ca2+]i), whereas diazoxide inhibits insulin secretion by opening K+-ATP channels.
Negative_regulation (inhibits) of Localization (secretion) of insulin
11) Confidence 0.54 Published 1998 Journal Diabetes Section Abstract Doc Link 9519741 Disease Relevance 0 Pain Relevance 0
It is suggested that clonidine inhibits glucose-stimulated insulin release by increasing the organelle sequestration of Ca2+.
Negative_regulation (inhibits) of Localization (release) of insulin associated with clonidine
12) Confidence 0.53 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6364277 Disease Relevance 0 Pain Relevance 0.44
Glucose-stimulated insulin release from pancreatic islets of ob/ob-mice was inhibited by 10(-9) M of the alpha 2-adrenergic agonist clonidine.
Negative_regulation (inhibited) of Localization (release) of insulin in pancreatic islets associated with agonist and clonidine
13) Confidence 0.53 Published 1983 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6364277 Disease Relevance 0 Pain Relevance 0.42
When used under our conditions, it almost entirely failed to alleviate the inhibition of insulin release induced by clonidine.
Negative_regulation (inhibition) of Localization (release) of insulin associated with clonidine
14) Confidence 0.52 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2572976 Disease Relevance 0 Pain Relevance 0.31
It is suggested that the main influence of beta-endorphin and met-enkephalin under in vivo conditions in the mouse is to inhibit stimulated insulin secretion.
Negative_regulation (inhibit) of Localization (secretion) of insulin associated with enkephalin
15) Confidence 0.51 Published 1989 Journal Int. J. Pancreatol. Section Abstract Doc Link 2574736 Disease Relevance 0 Pain Relevance 0.61
The neuropeptide galanin occurs in pancreatic adrenergic nerves and has been suggested to be the adrenergic mediator of the stress-induced inhibition of insulin release.
Negative_regulation (inhibition) of Localization (release) of insulin in nerves associated with stress and neuropeptide
16) Confidence 0.49 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7681407 Disease Relevance 0.10 Pain Relevance 0.25
cells to inhibit insulin secretion (Covey et al., 2006; Morioka et al., 2007); rather, they reveal an additional pathway whereby leptin fulfills this function.
Negative_regulation (inhibit) of Localization (secretion) of insulin
17) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.44 Pain Relevance 0
In contrast to osteocalcin, leptin inhibits insulin secretion in part through a direct effect on ?
Negative_regulation (inhibits) of Localization (secretion) of insulin
18) Confidence 0.47 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.26 Pain Relevance 0
Isolated islet perifusion studies demonstrated that exendin-(9-39) blocked amino acid-stimulated insulin secretion, which is abnormally increased in SUR-1(-/-) islets.
Negative_regulation (blocked) of Localization (secretion) of insulin
19) Confidence 0.46 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18635551 Disease Relevance 0.56 Pain Relevance 0.15
Congenital hyperinsulinism is a disorder of pancreatic beta-cell function characterized by failure to suppress insulin secretion in the setting of hypoglycemia, resulting in brain damage or death if untreated.
Negative_regulation (suppress) of Localization (secretion) of insulin in brain associated with hypoglycemia, persistent hyperinsulinemia hypoglycemia of infancy and death
20) Confidence 0.46 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18635551 Disease Relevance 0.45 Pain Relevance 0.10

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