INT18324

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Context Info
Confidence 0.46
First Reported 1989
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.09
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst, Ins1) extracellular region (Sst, Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Sst (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 13 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Antagonist 4 98.04 Very High Very High Very High
Clonidine 10 84.32 Quite High
tolerance 5 80.24 Quite High
agonist 4 73.20 Quite High
Disease Link Frequency Relevance Heat
Obesity 8 93.96 High High
Hyperglycemia 1 85.20 High High
Impaired Glucose Tolerance 5 80.88 Quite High
Insulin Resistance 1 77.68 Quite High
Bordatella Infection 6 38.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concomitant treatment with a potent somatostatin analog to inhibit insulin release blocked the effects of the alpha 2-adrenoceptor antagonist, compound A.
somatostatin Negative_regulation (inhibit) of Localization (release) of insulin associated with antagonist and somatostatin
1) Confidence 0.46 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1970847 Disease Relevance 0.92 Pain Relevance 0.90
Suppression of insulin release by galanin and somatostatin is mediated by a G-protein.
somatostatin Negative_regulation (Suppression) of Localization (release) of insulin associated with neuropeptide and somatostatin
2) Confidence 0.17 Published 1989 Journal J. Biol. Chem. Section Title Doc Link 2463254 Disease Relevance 0.09 Pain Relevance 0.19
Galanin (16 nM) and somatostatin (400 nM) suppressed glucose-stimulated insulin release in parallel to promoting repolarization and a reduction in [Ca2+]i.
somatostatin Negative_regulation (suppressed) of Localization (release) of insulin associated with somatostatin
3) Confidence 0.14 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2463254 Disease Relevance 0.09 Pain Relevance 0.15

General Comments

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