INT183240

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.52
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD2) plasma membrane (NOD2) enzyme binding (NOD2)
cytoplasm (NOD2)
Anatomy Link Frequency
corpus 2
bowel 1
NOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 25 99.84 Very High Very High Very High
Inflammation 49 92.52 High High
Fibrositis 97 51.92 Quite High
Pain 9 45.44 Quite Low
cytokine 21 33.16 Quite Low
spastic colon 1 20.88 Low Low
chemokine 12 11.76 Low Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 12 100.00 Very High Very High Very High
Disease 40 99.52 Very High Very High Very High
Familial Mediterranean Fever 25 94.60 High High
INFLAMMATION 47 92.52 High High
Syndrome 7 91.32 High High
Glioma 2 88.32 High High
Fever 3 86.52 High High
Apoptosis 1 71.08 Quite High
Crohn's Disease 18 60.64 Quite High
Death 3 57.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
results in a downregulation of a short alternatively spliced isoform of NOD2 encoding an auto-inhibitory CARD-only protein, which is generated by skipping of exon 3 [17].
Negative_regulation (downregulation) of NOD2
1) Confidence 0.43 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.36 Pain Relevance 0.15
and eIF4E in the control of the uORF-mediated translational repression of NOD2 as reported for other uORF-containing UTRs [18-22].


Negative_regulation (repression) of NOD2 associated with repression
2) Confidence 0.43 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0.10 Pain Relevance 0
Both APAF-1 (577 nt) and CARD4 (424 nt) transcripts exhibit much longer 5'UTRs as compared to 105 or 146 nucleotides in the deposited CARD15 mRNAs.
Negative_regulation (deposited) of CARD15
3) Confidence 0.42 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2228316 Disease Relevance 0 Pain Relevance 0
For example, using the pattern with $GENE$/$GENE$, the system will extract the co-occurrence pairs (CARD15, NOD2) and (MMAC, PTEN) from the following sentence fragments found in the corpus respectively:
Negative_regulation (pairs) of CARD15 in corpus
4) Confidence 0.41 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.09 Pain Relevance 0
This situation would be similar to the role of NOD2 in Crohn's disease, in which wild type NOD2, also a member of the NLR family [40], inhibits TLR2 (toll-like receptor-2) activation by peptidoglycan, while mutated NOD2 fails to inhibit TLR2, leading to chronic inflammation in the bowel [41].
Negative_regulation (role) of NOD2 in bowel associated with inflammation, crohn's disease and disease
5) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.89 Pain Relevance 0.19
For example, using the pattern with $GENE$/$GENE$, the system will extract the co-occurrence pairs (CARD15, NOD2) and (MMAC, PTEN) from the following sentence fragments found in the corpus respectively:
Negative_regulation (pairs) of NOD2 in corpus
6) Confidence 0.18 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.09 Pain Relevance 0

General Comments

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