INT183242

Context Info Confidence 0.55 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 3.81 Pain Relevance 0.16

lipid binding (PTEN) cell proliferation (PTEN) cytosol (PTEN) plasma membrane (PTEN) nucleus (PTEN) enzyme binding (PTEN)

PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 7 88.12 cytokine 4 87.40 agonist 9 74.00 psoriasis 1 33.12 COX2 2 24.76 cINOD 9 5.00 Migraine 4 5.00 positron emission tomography 2 5.00 aspirin 1 5.00 COX-2 inhibitor 1 5.00

Disease Link Frequency Relevance Heat Cholesteatoma 60 100.00 Cancer 186 99.84 Breast Cancer 35 99.56 Glioma 2 99.50 Rheumatoid Arthritis 27 97.92 Apoptosis 46 95.16 INFLAMMATION 10 88.12 Death 3 85.72 Lung Cancer 10 74.28 Thyroid Neoplasm 1 73.32

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inactivating mutations and decreased expression (either by LOH or methylation) of PTEN, a tumor suppressor that reverses the action of PI3K, are the most frequently observed aberrations.

Negative_regulation (decreased) of Gene_expression (expression) of PTEN associated with cancer

1) Confidence 0.55 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.80 Pain Relevance 0

gene expression via PPRE and downregulates phosphatase and tensin homolog (PTEN) protein expression, and subsequently leads to the activation of Akt1 in

Negative_regulation (downregulates) of Gene_expression (expression) of PTEN

2) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.61 Pain Relevance 0.04

Human glioma xenografts treated with PTEN/MMAC gene transfer exhibited...[33]

Negative_regulation (exhibited) of Gene_expression (transfer) of PTEN associated with glioma

3) Confidence 0.41 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

Human glioma xenografts treated with PTEN/MMAC gene transfer exhibited...[33]

Negative_regulation (exhibited) of Gene_expression (transfer) of MMAC associated with glioma

4) Confidence 0.41 Published 2005 Journal BMC Bioinformatics Section Body Doc Link PMC1090552 Disease Relevance 0.10 Pain Relevance 0

A further 15% to 35% of breast cancer patients demonstrate reduced expression of PTEN (phosphatase and tensin homolog deleted on chromosome ten), an endogenous inhibitor of the PI3K/Akt pathway [47].

Negative_regulation (reduced) of Gene_expression (expression) of PTEN associated with breast cancer

5) Confidence 0.33 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.54 Pain Relevance 0

Vasudevan reported that the tumor suppressor PTEN, which functions as a negative regulator of the phosphorylated Akt-mediated cell survival pathway in cholesteatoma, is downregulated by activated NF-?

Negative_regulation (downregulated) of Gene_expression (pathway) of PTEN associated with cancer and cholesteatoma

6) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 1.66 Pain Relevance 0.13

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