INT183249

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.40
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
platelet 4
coronary artery 1
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 105 100.00 Very High Very High Very High
adenocard 23 98.96 Very High Very High Very High
aspirin 159 96.88 Very High Very High Very High
Pain 46 92.00 High High
Dorsal horn 21 91.80 High High
hyperexcitability 3 91.04 High High
antagonist 25 90.08 High High
Dorsal horn neuron 9 89.96 High High
dorsal root ganglion 15 87.80 High High
COX-2 inhibitor 5 85.92 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 153 100.00 Very High Very High Very High
Atherosclerosis 38 99.76 Very High Very High Very High
Acute Coronary Syndrome 102 99.44 Very High Very High Very High
Diabetes Mellitus 28 96.08 Very High Very High Very High
Coronary Artery Disease 144 95.76 Very High Very High Very High
Nicotine Addiction 36 95.56 Very High Very High Very High
Hypertension 11 95.20 Very High Very High Very High
Disorder Of Lipid Metabolism 12 94.44 High High
Pain 43 92.00 High High
Disease 26 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hypothesis of interaction between the P2RY12 gene and variables involved in atherosclerotic risk was then evaluated.
P2RY12 gene Binding (interaction) of associated with atherosclerosis
1) Confidence 0.47 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 1.31 Pain Relevance 0
This study supports the previously reported association of P2RY12 gene with atherosclerosis, giving for the first time genetic association data for the presence of significant coronary artery disease, particularly in non-smoking individuals.
P2RY12 gene Binding (association) of in coronary artery associated with nicotine addiction, coronary artery disease and atherosclerosis
2) Confidence 0.35 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2048504 Disease Relevance 0.76 Pain Relevance 0
Are P2Y6 and P2Y12 receptors involved in neuropathic pain?
P2Y12 Binding (receptors) of associated with neuropathic pain
3) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.62 Pain Relevance 0.49
Activating P2Y12R and P2Y6R leads to chemotaxis and phagocytosis, respectively, but their functional relevance to neuropathic pain remained to be determined

P2X7 in neuropathic pain

P2Y12R Binding (leads) of associated with neuropathic pain
4) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 0.83 Pain Relevance 0.99
P2Y6 and P2Y12 in neuropathic pain?
P2Y12 Binding (pain) of associated with neuropathic pain
5) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072920 Disease Relevance 1.08 Pain Relevance 0.61
Detected single nucleotid polymorphisms of P2Y12 and GPIIIa receptors had been recognized as possible intrinsic mechanisms of clopidogrel resistance [8,9].


P2Y12 Binding (recognized) of
6) Confidence 0.16 Published 2009 Journal Thromb J Section Body Doc Link PMC2693432 Disease Relevance 0.44 Pain Relevance 0.06
In platelet membranes, RSNOs inhibited both basal and P2Y12 receptor-dependent G protein activity, but clearly potentiated ?
P2Y12 Binding (receptor) of in platelet
7) Confidence 0.14 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0
This so far unknown metabolite then irreversibly binds the P2Y12 receptor.
P2Y12 Binding (binds) of
8) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0.33 Pain Relevance 0.17
The current standard of care for ACS patients is dual antiplatelet therapy with aspirin and clopidogrel, although studies show that newer P2Y12 inhibitors, including prasugrel and ticagrelor, are more effective than clopidogrel.26,27 Limitations of clopidogrel include relatively slow onset of effect, low PAI in many patients, inter-individual variability in response, and irreversible P2Y12 binding that prevents rapid offset of effect.
P2Y12 Binding (binding) of associated with aspirin and acute coronary syndrome
9) Confidence 0.07 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2966970 Disease Relevance 0.50 Pain Relevance 0.13
ADP activates platelets by binding its purinergic P2Y1 and P2Y12 receptors.
P2Y12 Binding (binding) of in platelets
10) Confidence 0.05 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515423 Disease Relevance 0.31 Pain Relevance 0.21
Clopidogrel has a potent anti-thrombotic action by blocking P2Y12, a platelet ADP receptor, and also inhibits platelet aggregation induced by collagen.15)23)
P2Y12 Binding (aggregation) of in platelet
11) Confidence 0.05 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910288 Disease Relevance 0.49 Pain Relevance 0.37
Aspirin, which inhibits platelet activation by irreversibly binding to cyclooxygenase-1, is widely accepted as first-line treatment in ACS patients.2 By irreversibly binding the platelet P2Y12 receptor, thienopyridines inhibit adenosine disphosphate-mediated platelet activation.
platelet P2Y12 receptor Binding (binding) of in platelet associated with aspirin, acute coronary syndrome and adenocard
12) Confidence 0.01 Published 2009 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2729217 Disease Relevance 0.73 Pain Relevance 0.27

General Comments

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