INT183250

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry12) plasma membrane (P2ry12) signal transducer activity (P2ry12)
Anatomy Link Frequency
platelet 6
P2ry12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 76 97.24 Very High Very High Very High
COX-2 inhibitor 10 86.28 High High
Inflammatory response 2 75.04 Quite High
Osteoarthritis 4 56.52 Quite High
Cannabinoid 4 48.64 Quite Low
Serotonin 1 39.04 Quite Low
cINOD 10 35.44 Quite Low
agonist 21 5.00 Very Low Very Low Very Low
adenocard 14 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombosis 6 82.76 Quite High
Hyperplasia 4 76.12 Quite High
INFLAMMATION 4 74.64 Quite High
Injury 2 71.92 Quite High
Coronary Artery Disease 8 57.60 Quite High
Osteoarthritis 4 56.52 Quite High
Increased Venous Pressure Under Development 1 40.64 Quite Low
Cardiovascular Disease 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Alagille Syndrome 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In platelet membranes, RSNOs inhibited both basal and P2Y12 receptor-dependent G protein activity, but clearly potentiated ?
Negative_regulation (inhibited) of P2Y12 Binding (receptor) of in platelet
1) Confidence 0.16 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0
Clopidogrel has a potent anti-thrombotic action by blocking P2Y12, a platelet ADP receptor, and also inhibits platelet aggregation induced by collagen.15)23)
Negative_regulation (blocking) of P2Y12 Binding (aggregation) of in platelet
2) Confidence 0.06 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910288 Disease Relevance 0.49 Pain Relevance 0.37
Clopidogrel has a potent anti-thrombotic action by blocking P2Y12, a platelet ADP receptor, and also inhibits platelet aggregation induced by collagen.15)23)
Negative_regulation (inhibits) of P2Y12 Binding (aggregation) of in platelet
3) Confidence 0.06 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910288 Disease Relevance 0.49 Pain Relevance 0.37

General Comments

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