INT183269

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.61
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CEBPB, CPOX) mitochondrion (CPOX) small molecule metabolic process (CPOX)
oxidoreductase activity (CPOX) nucleus (CEBPB) DNA binding (CEBPB)
CEBPB (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 8 97.90 Very High Very High Very High
cytokine 9 90.08 High High
Inflammation 12 89.60 High High
Fibrositis 1 77.44 Quite High
Arthritis 1 76.04 Quite High
spinal inflammation 1 75.20 Quite High
Osteoarthritis 1 74.24 Quite High
rheumatoid arthritis 10 72.40 Quite High
Pain 2 69.24 Quite High
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 2 94.56 High High
Malignant Neoplastic Disease 4 92.56 High High
INFLAMMATION 11 89.60 High High
Fibromyalgia 1 77.44 Quite High
Syndrome 1 76.80 Quite High
Seronegative Spondarthritis 1 76.04 Quite High
Low Back Pain 1 75.20 Quite High
Osteoarthritis 1 74.24 Quite High
Systemic Lupus Erythematosus 1 73.60 Quite High
Rheumatoid Arthritis 10 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent papers suggest aspirin and salicylate at therapeutic concentrations inhibit COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer.
C/EBPbeta Binding (binding) of COX associated with aspirin
1) Confidence 0.07 Published 2005 Journal BMC Clin Pharmacol Section Body Doc Link PMC1090568 Disease Relevance 1.61 Pain Relevance 0.89

General Comments

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