INT183276

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 33
Disease Relevance 7.25
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adrm1) nucleus (Adrm1) cytoplasm (Adrm1)
Anatomy Link Frequency
arm 16
shoulder 7
neck 7
proximal 2
Adrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 150 98.96 Very High Very High Very High
antagonist 33 98.80 Very High Very High Very High
Dynorphin 147 94.72 High High
agonist 30 87.68 High High
amygdala 138 86.04 High High
addiction 24 85.60 High High
Pain 73 84.72 Quite High
Endogenous opioid 3 83.92 Quite High
Opioid 9 75.00 Quite High
alcohol 18 49.24 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 201 100.00 Very High Very High Very High
Cardiovascular Disease 105 99.76 Very High Very High Very High
Anxiety Disorder 138 98.82 Very High Very High Very High
Metabolic Syndrome 265 98.40 Very High Very High Very High
Sprains And Strains 3 95.36 Very High Very High Very High
Targeted Disruption 42 90.80 High High
Pain 97 84.72 Quite High
Stress 231 82.44 Quite High
Weight Loss 40 79.68 Quite High
Hyperlipidemia 31 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the still high percentage of workers suffering from arm, shoulder and neck symptoms, further studies on the effect of interventions in reducing arm, shoulder and neck symptoms in occupational settings are recommended.


Negative_regulation (reducing) of arm in neck
1) Confidence 0.04 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
In fact, when we tested our mice under conditions where the ambient light was much brighter, we saw a decrease in the open arm time as predicted.
Negative_regulation (decrease) of arm in arm
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.80 Pain Relevance 0.15
The reduction in open-arm time was blocked by pretreatment with the KOR antagonist norbinaltorphimine (norBNI), and was not evident in mice lacking the endogenous KOR ligand dynorphin.
Negative_regulation (blocked) of arm in arm associated with dynorphin, antagonist and kappa opioid receptor
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.49 Pain Relevance 0.74
We operationally use the term ‘anxiety’ to describe the increase in percent time spent in a dark closed arm of the EPM, although the actual mood state of the mouse cannot be directly determined.
Negative_regulation (closed) of arm in arm associated with anxiety disorder
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.79 Pain Relevance 0.30
Furthermore, the focus on arm, shoulder and neck symptoms in the participating companies may also have caused greater awareness of the risks attributed to computer use and may have contributed to the overall decline of risk factors and arm, shoulder and neck symptoms.
Negative_regulation (decline) of arm in shoulder
5) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0.07 Pain Relevance 0.07
There were no significant differences in the changes in prevalence of arm, shoulder and neck symptoms between the intervention and usual care group.
Negative_regulation (prevalence) of arm in arm
6) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
The overall prevalence of arm, shoulder and neck symptoms was divided into two subgroups: proximal (neck, upper-back and shoulders) and distal (elbows, forearms, wrists and hands) symptoms.
Negative_regulation (prevalence) of arm in proximal
7) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
This feedback was given after completing each section of the questionnaire and consisted of scores on a scale from 1 to 10, a visual representation of the score with a graph, an interpretation of the score and an elaborate advice on the specific actions that they could personally take in order to reduce their risk of arm, shoulder and neck symptoms (Figure 2).
Negative_regulation (reduce) of arm in neck
8) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
For the dichotomous outcome variables, i.e., information, eyesight, prevalence of (overall, proximal and distal) arm, shoulder and neck symptoms, logistic multilevel regression analysis were used.
Negative_regulation (prevalence) of arm in proximal
9) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0.04
The overall prevalence of arm, shoulder and neck symptoms decreased by 9% in both the intervention (decrease from 51% to 42%) and usual care group (decrease from 56% to 47%).
Negative_regulation (prevalence) of arm in shoulder
10) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
The primary outcome measure was the prevalence of arm, shoulder and neck symptoms.
Negative_regulation (prevalence) of arm in neck
11) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0.08 Pain Relevance 0.08
The prevalence of arm, shoulder and neck symptoms was estimated with the questionnaire, which used a slightly altered version of the Nordic Questionnaire by Kuorinka et al. [16].
Negative_regulation (prevalence) of arm
12) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0.06 Pain Relevance 0.06
Exposure to most risk factors and prevalence of arm, shoulder and neck symptoms decreased in both groups.
Negative_regulation (prevalence) of arm in arm
13) Confidence 0.03 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
Given the still high percentage of workers suffering from arm, shoulder and neck symptoms, further studies on the effect of interventions in reducing arm, shoulder and neck symptoms in occupational settings are recommended.


Negative_regulation (reducing) of arm in arm
14) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
Given the still high percentage of workers suffering from arm, shoulder and neck symptoms, further studies on the effect of interventions in reducing arm, shoulder and neck symptoms in occupational settings are recommended.


Negative_regulation (reducing) of arm in shoulder
15) Confidence 0.02 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
Furthermore, the focus on arm, shoulder and neck symptoms in the participating companies may also have caused greater awareness of the risks attributed to computer use and may have contributed to the overall decline of risk factors and arm, shoulder and neck symptoms.
Negative_regulation (decline) of arm in arm
16) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0.07 Pain Relevance 0.07
Furthermore, the focus on arm, shoulder and neck symptoms in the participating companies may also have caused greater awareness of the risks attributed to computer use and may have contributed to the overall decline of risk factors and arm, shoulder and neck symptoms.
Negative_regulation (decline) of arm in neck
17) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0.07 Pain Relevance 0.07
There were no significant differences in the changes in prevalence of arm, shoulder and neck symptoms between the intervention and usual care group.
Negative_regulation (prevalence) of arm in shoulder
18) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0
The primary outcome measure was the prevalence of arm, shoulder and neck symptoms.
Negative_regulation (prevalence) of arm in arm
19) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0.08 Pain Relevance 0.08
There were no significant differences in the changes in prevalence of arm, shoulder and neck symptoms between the intervention and usual care group.
Negative_regulation (prevalence) of arm in neck
20) Confidence 0.01 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890602 Disease Relevance 0 Pain Relevance 0

General Comments

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