INT18334

Context	Info
Confidence	0.69
First Reported	1990
Last Reported	2010
Negated	0
Speculated	0
Reported most in	Abstract
Documents	24
Total Number	24
Disease Relevance	2.98
Pain Relevance	11.22

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peptidase activity (Cpb2)

extracellular space (Cpb2)

extracellular region (Cpb2)

Anatomy Link	Frequency
CPu	6
ventral	6
striatum	3
forebrain	2
dorsal	1

Cpb2 (Rattus norvegicus)

Pain Link	Frequency	Relevance
Nucleus accumbens	100	100.00
gABA	48	100.00
nMDA receptor	34	100.00
Central grey	27	100.00
withdrawal	14	99.20
Morphine	30	99.06
antagonist	12	98.74
dopamine receptor	1	98.52
Neuropeptide	28	98.16
Enkephalin	14	97.58

Disease Link	Frequency	Relevance
Urological Neuroanatomy	29	100.00
Stress	8	99.50
Acute Coronary Syndrome	96	98.98
Psychosis	8	93.16
Emergencies	8	91.60
Schizophrenia	10	88.24
Nociception	3	87.12
Injury	6	83.32
Coronary Artery Disease	2	82.12
Drug Dependence	8	77.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Similarly, PPD mRNA expression was increased in all aspects of the striatum at 80 mg/kg (dlCPu, dmCPu, vlCPu, vmCPu and aCPu, +98%, +25%, +104%, +9% and +85%, respectively).

Positive_regulation (increased) of vmCPu in striatum

1)	Confidence	0.69	Published	1997	Journal	Neurosci. Lett.	Section	Abstract	Doc Link	9280160	Disease Relevance	0.08	Pain Relevance	0.34

Similarly, PPD mRNA expression was increased in all aspects of the striatum at 80 mg/kg (dlCPu, dmCPu, vlCPu, vmCPu and aCPu, +98%, +25%, +104%, +9% and +85%, respectively).

Positive_regulation (increased) of dmCPu in striatum

2)	Confidence	0.50	Published	1997	Journal	Neurosci. Lett.	Section	Abstract	Doc Link	9280160	Disease Relevance	0.08	Pain Relevance	0.33

Similarly, PPD mRNA expression was increased in all aspects of the striatum at 80 mg/kg (dlCPu, dmCPu, vlCPu, vmCPu and aCPu, +98%, +25%, +104%, +9% and +85%, respectively).

Positive_regulation (increased) of vlCPu in striatum

3)	Confidence	0.50	Published	1997	Journal	Neurosci. Lett.	Section	Abstract	Doc Link	9280160	Disease Relevance	0.08	Pain Relevance	0.33

Veratridine administered at 75 microM, produced a 45-fold increase in GABA overflow in the intact CPu, but failed to produce any effect in the lesioned CPu.

Positive_regulation (increase) of CPu in CPu associated with gaba

4)	Confidence	0.46	Published	1993	Journal	Brain Res.	Section	Abstract	Doc Link	8348317	Disease Relevance	0	Pain Relevance	0.65

KCl added to the perfusion fluid at a concentration of 100 mM resulted in dramatic increases in GABA overflow from baseline levels in the intact CPu (60- to 70-fold), which were almost totally abolished (> 95%) in the excitotoxically lesioned CPu.

Positive_regulation (increases) of CPu in CPu associated with gaba

5)	Confidence	0.40	Published	1993	Journal	Brain Res.	Section	Abstract	Doc Link	8348317	Disease Relevance	0	Pain Relevance	0.54

The addition of nipecotic acid (0.5 mM), a GABA uptake blocker, increased basal extracellular GABA levels 6-15-fold in the intact CPu, while GABA overflow in either the acute or chronic lesioned CPu was not significantly altered.

Positive_regulation (increased) of CPu in CPu associated with gaba

6)	Confidence	0.40	Published	1993	Journal	Brain Res.	Section	Abstract	Doc Link	8348317	Disease Relevance	0	Pain Relevance	0.72

In contrast, co-administration of haloperidol (dopamine receptor antagonist) with MK-801 blocked the effect of the latter in the NAc, and elevated PPE mRNA levels throughout the CPu.

Positive_regulation (elevated) of CPu in CPu associated with nucleus accumbens, antagonist and dopamine receptor

7)	Confidence	0.32	Published	1996	Journal	Neurosci. Lett.	Section	Abstract	Doc Link	8848257	Disease Relevance	0.07	Pain Relevance	0.56

As compared to an acute dose of morphine in a naive animal, the induction of c-Fos was increased in the dorsolateral CPu following challenge injection at 7 days, but not at 14 days.

Positive_regulation (increased) of CPu in CPu associated with morphine

8)	Confidence	0.29	Published	1999	Journal	Brain Res.	Section	Abstract	Doc Link	10415375	Disease Relevance	0	Pain Relevance	0.98

They also support the idea that the undesirable motoric signs and symptoms observed after chronic treatment with typical neuroleptics may not be the result of increased levels of enkephalins in the basal ganglia because atypical neuroleptics which are almost totally devoid of these side effects caused similar increases in PEK mRNA in the CPU.

Positive_regulation (increases) of CPU in basal ganglia associated with enkephalin

9)	Confidence	0.28	Published	1990	Journal	J. Neurochem.	Section	Abstract	Doc Link	1971007	Disease Relevance	0	Pain Relevance	0.40

Administration of MK-801 once daily for 7 consecutive days increased the abundance of all three neuropeptide mRNAs in the caudate-putamen (CPU) and nucleus accumbens (NAc). (1) PPE mRNA abundance was increased in the anterior CPU (26%) as well as dorsal and ventral CPU (46% and 39%, respectively) but was unaffected in the NAc. (2) PPT mRNA was increased in the NAc (33%), anterior CPU (27%), dorsal CPU (43%) and ventral CPU (67%).