INT18334

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 2.98
Pain Relevance 11.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpb2) extracellular space (Cpb2) extracellular region (Cpb2)
Anatomy Link Frequency
CPu 6
ventral 6
striatum 3
forebrain 2
dorsal 1
Cpb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 100 100.00 Very High Very High Very High
gABA 48 100.00 Very High Very High Very High
nMDA receptor 34 100.00 Very High Very High Very High
Central grey 27 100.00 Very High Very High Very High
withdrawal 14 99.20 Very High Very High Very High
Morphine 30 99.06 Very High Very High Very High
antagonist 12 98.74 Very High Very High Very High
dopamine receptor 1 98.52 Very High Very High Very High
Neuropeptide 28 98.16 Very High Very High Very High
Enkephalin 14 97.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 29 100.00 Very High Very High Very High
Stress 8 99.50 Very High Very High Very High
Acute Coronary Syndrome 96 98.98 Very High Very High Very High
Psychosis 8 93.16 High High
Emergencies 8 91.60 High High
Schizophrenia 10 88.24 High High
Nociception 3 87.12 High High
Injury 6 83.32 Quite High
Coronary Artery Disease 2 82.12 Quite High
Drug Dependence 8 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, PPD mRNA expression was increased in all aspects of the striatum at 80 mg/kg (dlCPu, dmCPu, vlCPu, vmCPu and aCPu, +98%, +25%, +104%, +9% and +85%, respectively).
Positive_regulation (increased) of vmCPu in striatum
1) Confidence 0.69 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9280160 Disease Relevance 0.08 Pain Relevance 0.34
Similarly, PPD mRNA expression was increased in all aspects of the striatum at 80 mg/kg (dlCPu, dmCPu, vlCPu, vmCPu and aCPu, +98%, +25%, +104%, +9% and +85%, respectively).
Positive_regulation (increased) of dmCPu in striatum
2) Confidence 0.50 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9280160 Disease Relevance 0.08 Pain Relevance 0.33
Similarly, PPD mRNA expression was increased in all aspects of the striatum at 80 mg/kg (dlCPu, dmCPu, vlCPu, vmCPu and aCPu, +98%, +25%, +104%, +9% and +85%, respectively).
Positive_regulation (increased) of vlCPu in striatum
3) Confidence 0.50 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9280160 Disease Relevance 0.08 Pain Relevance 0.33
Veratridine administered at 75 microM, produced a 45-fold increase in GABA overflow in the intact CPu, but failed to produce any effect in the lesioned CPu.
Positive_regulation (increase) of CPu in CPu associated with gaba
4) Confidence 0.46 Published 1993 Journal Brain Res. Section Abstract Doc Link 8348317 Disease Relevance 0 Pain Relevance 0.65
KCl added to the perfusion fluid at a concentration of 100 mM resulted in dramatic increases in GABA overflow from baseline levels in the intact CPu (60- to 70-fold), which were almost totally abolished (> 95%) in the excitotoxically lesioned CPu.
Positive_regulation (increases) of CPu in CPu associated with gaba
5) Confidence 0.40 Published 1993 Journal Brain Res. Section Abstract Doc Link 8348317 Disease Relevance 0 Pain Relevance 0.54
The addition of nipecotic acid (0.5 mM), a GABA uptake blocker, increased basal extracellular GABA levels 6-15-fold in the intact CPu, while GABA overflow in either the acute or chronic lesioned CPu was not significantly altered.
Positive_regulation (increased) of CPu in CPu associated with gaba
6) Confidence 0.40 Published 1993 Journal Brain Res. Section Abstract Doc Link 8348317 Disease Relevance 0 Pain Relevance 0.72
In contrast, co-administration of haloperidol (dopamine receptor antagonist) with MK-801 blocked the effect of the latter in the NAc, and elevated PPE mRNA levels throughout the CPu.
Positive_regulation (elevated) of CPu in CPu associated with nucleus accumbens, antagonist and dopamine receptor
7) Confidence 0.32 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 8848257 Disease Relevance 0.07 Pain Relevance 0.56
As compared to an acute dose of morphine in a naive animal, the induction of c-Fos was increased in the dorsolateral CPu following challenge injection at 7 days, but not at 14 days.
Positive_regulation (increased) of CPu in CPu associated with morphine
8) Confidence 0.29 Published 1999 Journal Brain Res. Section Abstract Doc Link 10415375 Disease Relevance 0 Pain Relevance 0.98
They also support the idea that the undesirable motoric signs and symptoms observed after chronic treatment with typical neuroleptics may not be the result of increased levels of enkephalins in the basal ganglia because atypical neuroleptics which are almost totally devoid of these side effects caused similar increases in PEK mRNA in the CPU.
Positive_regulation (increases) of CPU in basal ganglia associated with enkephalin
9) Confidence 0.28 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1971007 Disease Relevance 0 Pain Relevance 0.40
Administration of MK-801 once daily for 7 consecutive days increased the abundance of all three neuropeptide mRNAs in the caudate-putamen (CPU) and nucleus accumbens (NAc). (1) PPE mRNA abundance was increased in the anterior CPU (26%) as well as dorsal and ventral CPU (46% and 39%, respectively) but was unaffected in the NAc. (2) PPT mRNA was increased in the NAc (33%), anterior CPU (27%), dorsal CPU (43%) and ventral CPU (67%).
Positive_regulation (increased) of CPU in ventral associated with nucleus accumbens and neuropeptide
10) Confidence 0.23 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.40
Administration of MK-801 once daily for 7 consecutive days increased the abundance of all three neuropeptide mRNAs in the caudate-putamen (CPU) and nucleus accumbens (NAc). (1) PPE mRNA abundance was increased in the anterior CPU (26%) as well as dorsal and ventral CPU (46% and 39%, respectively) but was unaffected in the NAc. (2) PPT mRNA was increased in the NAc (33%), anterior CPU (27%), dorsal CPU (43%) and ventral CPU (67%).
Positive_regulation (increased) of CPU in ventral associated with nucleus accumbens and neuropeptide
11) Confidence 0.23 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.49
Administration of MK-801 once daily for 7 consecutive days increased the abundance of all three neuropeptide mRNAs in the caudate-putamen (CPU) and nucleus accumbens (NAc). (1) PPE mRNA abundance was increased in the anterior CPU (26%) as well as dorsal and ventral CPU (46% and 39%, respectively) but was unaffected in the NAc. (2) PPT mRNA was increased in the NAc (33%), anterior CPU (27%), dorsal CPU (43%) and ventral CPU (67%).
Positive_regulation (increased) of CPU in ventral associated with nucleus accumbens and neuropeptide
12) Confidence 0.23 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.46
Administration of MK-801 once daily for 7 consecutive days increased the abundance of all three neuropeptide mRNAs in the caudate-putamen (CPU) and nucleus accumbens (NAc). (1) PPE mRNA abundance was increased in the anterior CPU (26%) as well as dorsal and ventral CPU (46% and 39%, respectively) but was unaffected in the NAc. (2) PPT mRNA was increased in the NAc (33%), anterior CPU (27%), dorsal CPU (43%) and ventral CPU (67%).
Positive_regulation (increased) of CPU in ventral associated with nucleus accumbens and neuropeptide
13) Confidence 0.23 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.41
Administration of MK-801 once daily for 7 consecutive days increased the abundance of all three neuropeptide mRNAs in the caudate-putamen (CPU) and nucleus accumbens (NAc). (1) PPE mRNA abundance was increased in the anterior CPU (26%) as well as dorsal and ventral CPU (46% and 39%, respectively) but was unaffected in the NAc. (2) PPT mRNA was increased in the NAc (33%), anterior CPU (27%), dorsal CPU (43%) and ventral CPU (67%).
Positive_regulation (increased) of CPU in ventral associated with nucleus accumbens and neuropeptide
14) Confidence 0.23 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.46
In the ventral CPU, PPT mRNA abundance doubled when the dose of MK-801 increased two-fold (from 67% to 119% above control). (3) PPD mRNA was elevated in dorsal and ventral regions of the CPU (49% and 24%, respectively) and in anterior CPU (50%).
Positive_regulation (elevated) of CPU in dorsal
15) Confidence 0.23 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.49
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Positive_regulation (increased) of CPU in forebrain associated with nmda receptor
16) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.30
Under this withdrawal-related stress condition, there was an increase in MOP-r mRNA levels in the lat.hyp, NAc core, and CPu.
Positive_regulation (increase) of CPu in NAc associated with stress, nucleus accumbens and withdrawal
17) Confidence 0.20 Published 2006 Journal J. Endocrinol. Section Abstract Doc Link 17065397 Disease Relevance 0.19 Pain Relevance 1.23
Opiates and psychostimulants produce many shared behavioral and neurobiological adaptations, such as behavioral sensitization and the induction of immediate early genes in the caudate-putamen (CPu).
Positive_regulation (induction) of CPu in CPu associated with opiate
18) Confidence 0.18 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138436 Disease Relevance 0 Pain Relevance 0.38
THIM administration led to increase of MOR density in the PAG (a–d) and the CPU (g–h) (increase pointed with black arrows), but to decrease of MOR density in the DG (e–f) (decrease pointed with white arrows). a DMPAG, control, 8-week, ×400; b DMPAG, 240 ?
Positive_regulation (increase) of CPU associated with central grey
19) Confidence 0.17 Published 2010 Journal Neurochem Res Section Body Doc Link PMC2957583 Disease Relevance 0.49 Pain Relevance 0.25
This study aimed to analyze current characteristics, disposition and outcome of patients with suspected ACS in a traditional ED, and to explore the basis for establishing a CPU.
Positive_regulation (establishing) of CPU associated with acute coronary syndrome
20) Confidence 0.14 Published 2002 Journal BMC Emerg Med Section Body Doc Link PMC130966 Disease Relevance 0.54 Pain Relevance 0.05

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