INT183360

Context Info Confidence 0.27 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 13 Total Number 13 Disease Relevance 7.68 Pain Relevance 2.19

Anatomy Link Frequency smooth muscle 1 B-cell 1 synovium 1 Cr2 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 811 100.00 Inflammation 97 91.84 Arthritis 15 91.68 cva 3 82.64 spastic colon 1 66.56 chemokine 21 65.60 Adalimumab 8 59.24 imagery 4 39.28 cytokine 55 27.76 vincristine 2 7.28

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 811 100.00 Cancer 59 99.50 Severe Combined Immunodeficiency 112 94.24 Follicular Dendritic Cell Sarcoma 4 93.36 INFLAMMATION 107 91.84 Arthritis 22 91.68 Fibrosarcoma 5 90.80 Dengue 128 87.52 Gastrointestinal Stromal Tumor 1 86.72 Disease Progression 1 86.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

(ii) AID and CD21L expression in RA synovial grafts is associated with the up-regulation of genes regulating ectopic lymphoneogenesis.

CD21L Binding (associated) of associated with rheumatoid arthritis

1) Confidence 0.27 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.65 Pain Relevance 0.33

m paraffin and/or frozen sections of five RA synovial samples representative of different degrees of histological organization (three aggregate/CD21+, one aggregate/CD21?

CD21 Binding (aggregate) of associated with rheumatoid arthritis

2) Confidence 0.27 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.35 Pain Relevance 0.18

We identified by IHC an aggregate pattern AID+/CD21+ in seven patients (28%), aggregate pattern AID?

CD21 Binding (pattern) of

3) Confidence 0.27 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.58 Pain Relevance 0.29

A total of 56 samples of human synovium from six patients with RA undergoing arthroplasty (classified prior to transplantation histologically as two diffuse, two aggregate/CD21?

CD21 Binding (aggregate) of in synovium associated with rheumatoid arthritis

4) Confidence 0.27 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.30 Pain Relevance 0.10

m paraffin and/or frozen sections of five RA synovial samples representative of different degrees of histological organization (three aggregate/CD21+, one aggregate/CD21?

CD21 Binding (aggregate) of associated with rheumatoid arthritis

5) Confidence 0.27 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.36 Pain Relevance 0.18

m paraffin and/or frozen sections of five RA synovial samples representative of different degrees of histological organization (three aggregate/CD21+, one aggregate/CD21?

CD21 Binding (aggregate) of associated with rheumatoid arthritis

6) Confidence 0.27 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.35 Pain Relevance 0.18

Indeed, AID mRNA expression was detected in all 12 of the CD21L+ RA samples but in none of the 13 CD21L?

CD21L Neg (none) Binding (none) of associated with rheumatoid arthritis

7) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.46 Pain Relevance 0.23

Runaway complement activation is prevented by binding of Complement Receptor 1 (CR1) and a constitutively active membrane bound Decay Accelerating Factor (DAF, or CD55) which can prevent the complement cascade[51].

Complement Receptor 1 Binding (binding) of

8) Confidence 0.19 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.50 Pain Relevance 0.04

Runaway complement activation is prevented by binding of Complement Receptor 1 (CR1) and a constitutively active membrane bound Decay Accelerating Factor (DAF, or CD55) which can prevent the complement cascade[51].

CR1 Binding (binding) of

9) Confidence 0.19 Published 2009 Journal Virol J Section Body Doc Link PMC2789730 Disease Relevance 0.50 Pain Relevance 0.04

Tumor cells were negative for cytokeratin, CD45, CD20, CD3, CD30, CD68, CD35 and CD1a; Ki-67 was positive in about 15% of the cells.

CD35 Binding (cytokeratin) of associated with cancer

10) Confidence 0.13 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2556649 Disease Relevance 0.64 Pain Relevance 0

CD86 is upregulated on activated B cells upon B-cell receptor (BCR) and CD19/CD21 complex engagement [24,25].

CD21 Binding (engagement) of in B-cell

11) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888223 Disease Relevance 0.85 Pain Relevance 0.30

, and negative for CD3, CD10, CD21, CD23, and CD43.

CD21 Binding (negative) of

12) Confidence 0.04 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2933587 Disease Relevance 0.24 Pain Relevance 0

The spindle cells stain positively for smooth muscle actin and vimentin but are negative for S100, desmin, CD100, cytokeratin, CD35 and latent membrane protein.

CD35 Binding (negative) of in smooth muscle

13) Confidence 0.04 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1097763 Disease Relevance 1.90 Pain Relevance 0.33

General Comments

This test has worked.