INT183371

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.27
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Galc) hydrolase activity, acting on glycosyl bonds (Galc) carbohydrate metabolic process (Galc)
lysosome (Galc)
Anatomy Link Frequency
cerebellum 1
Galc (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 370 99.72 Very High Very High Very High
cytokine 74 95.60 Very High Very High Very High
Nerve growth factor 41 94.72 High High
Multiple sclerosis 90 90.68 High High
Inflammatory mediators 10 87.96 High High
Inflammation 150 79.20 Quite High
Crohn's disease 10 73.96 Quite High
rheumatoid arthritis 10 73.16 Quite High
Infliximab 10 71.52 Quite High
Etanercept 10 71.12 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 550 99.72 Very High Very High Very High
Disease 112 99.44 Very High Very High Very High
INFLAMMATION 170 87.56 High High
Rheumatoid Arthritis 17 83.60 Quite High
Multiple Sclerosis 50 77.84 Quite High
Apoptosis 130 74.92 Quite High
Hypersensitivity 10 66.64 Quite High
Targeted Disruption 10 53.44 Quite High
Adrenoleukodystrophy 10 51.80 Quite High
Drug Induced Neurotoxicity 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, mRNA for TNFR2 increased in twi/twi only after PND 40, when compared with that for +/+ (Fig. 1B).
Positive_regulation (increased) of twi
1) Confidence 0.67 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.15 Pain Relevance 0.05
The clinical symptoms were improved in only two ibudilast-treated twi/twi, whereas the demyelination was milder in all of the treated twi/twi.
Positive_regulation (treated) of twi associated with demyelination
2) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.88 Pain Relevance 0.48
The clinical symptoms were improved in only two ibudilast-treated twi/twi, whereas the demyelination was milder in all of the treated twi/twi.
Positive_regulation (treated) of twi associated with demyelination
3) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.88 Pain Relevance 0.48
mRNA were remarkably suppressed in the areas of severe demyelination in ibudilast-treated twi/twi, the effect of ibudilast may be mediated, at leaset in part, by the suppression of TNF?
Positive_regulation (treated) of twi associated with demyelination
4) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 1.08 Pain Relevance 0.63
Since inducible nitric oxide (iNOS) and IL-6 were strongly upregulated in twi/twi and Krabbe's disease [10,11,31], the positive effect of ibudilast may be also associated with suppression of iNOS and IL-6, and enhancement of inhibitory cytokines and neurotrophic factors.
Positive_regulation (upregulated) of twi associated with disease and cytokine
5) Confidence 0.49 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 1.34 Pain Relevance 0.53
In contrast, mRNA for TNFR2 increased in twi/twi only after PND 40, when compared with that for +/+ (Fig. 1B).
Positive_regulation (increased) of twi
6) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.15 Pain Relevance 0.05
mRNA level between twi/twi and +/+ at PND 20, however, its level increased significantly in twi/twi after PND 30, becoming 40 times higher in twi/twi than +/+ at PND 40 (Fig. 1A).
Positive_regulation (increased) of twi
7) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.14 Pain Relevance 0.04
In the +/+ cerebellum, the level of TNFR1 mRNA was constant throughout all the ages examined, whereas in the twi/twi cerebellum, it significantly increased with the progression of demyelination, becoming 50 times higher than that in +/+ at PND 40.
Positive_regulation (increased) of twi in cerebellum associated with demyelination
8) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 0.15 Pain Relevance 0.05
tubulin III, GFAP and GalC were processed from the cultures as described above.
Positive_regulation (processed) of GalC
9) Confidence 0.23 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.08 Pain Relevance 0.04
Since inducible nitric oxide (iNOS) and IL-6 were strongly upregulated in twi/twi and Krabbe's disease [10,11,31], the positive effect of ibudilast may be also associated with suppression of iNOS and IL-6, and enhancement of inhibitory cytokines and neurotrophic factors.
Positive_regulation (upregulated) of twi associated with disease and cytokine
10) Confidence 0.21 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 1.34 Pain Relevance 0.53
mRNA were remarkably suppressed in the areas of severe demyelination in ibudilast-treated twi/twi, the effect of ibudilast may be mediated, at leaset in part, by the suppression of TNF?
Positive_regulation (treated) of twi associated with demyelination
11) Confidence 0.21 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 1.08 Pain Relevance 0.63

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