INT183387

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Il10) extracellular region (Il6, Il10) intracellular (Il10)
Anatomy Link Frequency
nerve 2
Il6 (Mus musculus)
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 100.00 Very High Very High Very High
Nerve growth factor 4 98.48 Very High Very High Very High
Inflammatory mediators 1 98.40 Very High Very High Very High
Central nervous system 29 90.32 High High
Inflammation 20 89.64 High High
Demyelination 39 86.36 High High
Multiple sclerosis 21 67.68 Quite High
Infliximab 1 22.88 Low Low
Etanercept 1 21.68 Low Low
rheumatoid arthritis 1 18.40 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 98.00 Very High Very High Very High
Demyelinating Disease 57 92.96 High High
Central Nervous System Disease 21 90.32 High High
Multiple Sclerosis 55 88.48 High High
Apoptosis 14 85.36 High High
Disease 15 81.60 Quite High
Targeted Disruption 2 63.88 Quite High
Adrenoleukodystrophy 1 62.24 Quite High
Rheumatoid Arthritis 1 18.40 Low Low
Paralysis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and IL-6 enhanced IL-10 production in a dose-dependent manner (Figure 6D).
IL-6 Positive_regulation (enhanced) of Gene_expression (production) of IL-10
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.25 Pain Relevance 0.05
, and IL-6, and enhanced the production of the inhibitory cytokine, IL-10, and neurotrophic factors, including nerve growth factor (NGF), glia-derived neurotrophic factor (GDNF) and neurotrophin (NT-4) [30].
IL-6 Positive_regulation (enhanced) of Gene_expression (production) of IL-10 in nerve associated with nerve growth factor and cytokine
2) Confidence 0.02 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1112612 Disease Relevance 1.55 Pain Relevance 0.58

General Comments

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