INT183394

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.17
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
eosinophils 2
precursor cells 1
tails 1
brain 1
oligodendrocytes 1
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 98.48 Very High Very High Very High
Nav1.6 11 91.44 High High
ischemia 16 89.48 High High
Inflammation 86 85.68 High High
Hippocampus 10 69.36 Quite High
Neurotransmitter 40 50.00 Quite Low
anesthesia 6 48.80 Quite Low
Multiple sclerosis 31 5.00 Very Low Very Low Very Low
Action potential 31 5.00 Very Low Very Low Very Low
Demyelination 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 10 100.00 Very High Very High Very High
Disease 105 98.98 Very High Very High Very High
Asthma 89 98.54 Very High Very High Very High
Alzheimer's Dementia 20 90.88 High High
Cv Unclassified Under Development 12 89.48 High High
Airway Remodeling 28 87.12 High High
Cancer 67 87.04 High High
INFLAMMATION 90 85.68 High High
Bronchitis 9 78.60 Quite High
Hypertrophy 1 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
 ; 1:500, Chemicon) and anti-olig2 (1:500, Chemicon); mature oligodendrocytes: anti-glutathione S transferase-pi (GST-pi; 1:1000, Chemicon) and PLP-EGFP fluorescence; myelin: anti-myelin basic protein (1:1000, Chemicon); microglia/macrophage/monocyte: anti-CD45 (1:1000; PharMingen, La Jolla, CA); macrophages: Mac3 (1:500; BD Biosciences, San Diego, CA); T cells: anti-CD3 (1:1000, Abcam); nodal proteins: Caspr, Nav1.6, Kv1.2 (Alomone Labs, Jerusalem, Israel and Antibodies Inc, Davis, CA) were used.
Localization (fluorescence) of anti-myelin basic protein in oligodendrocytes associated with nav1.6
1) Confidence 0.54 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.31 Pain Relevance 0.09
One possible explanation is that the increased numbers of eosinophils in the airway in Siglec-F deficient mice express increased levels of mediators that can influence mucus secretion including granule mediators (ECP, MBP)[29,30], lipid mediators (LTC4)[31], cytokines (IL-13)[31], or other at present unknown mediators.
Localization (secretion) of MBP in eosinophils associated with cytokine
2) Confidence 0.50 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.40 Pain Relevance 0.05
Syntaxin-1, SNAP-25, the mixture of syntaxin-1 and SNAP-25, or the mixture of syntaxin-1, SNAP-25, and VAMP-2 was incubated with MBP, MBP-tomosyn-?
Localization (tomosyn) of MBP
3) Confidence 0.36 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.06 Pain Relevance 0
Several studies have shown that asthmatic airway tissue, unlike non-asthmatic controls, is characterized by a preponderance of activated eosinophils, releasing MBP, around cholinergic nerve fibres [14,15].
Localization (releasing) of MBP in eosinophils associated with asthma
4) Confidence 0.27 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 1.52 Pain Relevance 0.08
Interestingly, in c. striatum, GPR17+ precursor cells were not positive for MBP, but were often found physically associated to or inside myelinating fibers (Figure S2).
Neg (not) Localization (positive) of MBP in precursor cells
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2570486 Disease Relevance 0.09 Pain Relevance 0.08
In addition, both DNMT1 and methyl-binding proteins (MBP), such as methyl-CpG-binding protein 2 (MeCP2) recruit histone deacetylases which deacetilate histone core tails leading to tighter chromatin packaging, reducing the access of transcriptional factors to DNA [11,12].
Localization (recruit) of MBP in tails
6) Confidence 0.25 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 0.19 Pain Relevance 0
Syntaxin-1, SNAP-25, the mixture of syntaxin-1 and SNAP-25, or the mixture of syntaxin-1, SNAP-25, and VAMP-2 was incubated with MBP, MBP-tomosyn-?
Localization (tomosyn) of MBP
7) Confidence 0.16 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.06 Pain Relevance 0
Previously we demonstrated that the ultrastructural features of cortical neurons from AD brain biopsies are characterized by the selective localization of mitochondria abnormalities to the cell bodies (Aliev et al 1999, 2000; Hirai et al 2001; Aliev 2002; Shi et al 2002b).
Localization (localization) of Shi in brain associated with congenital anomalies and disease
8) Confidence 0.12 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515433 Disease Relevance 0.55 Pain Relevance 0

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