INT183395

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.76
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
tails 2
paw 1
Mecp2 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 98 93.36 High High
midbrain 12 82.04 Quite High
antidepressant 62 79.36 Quite High
depression 73 78.60 Quite High
Hippocampus 44 5.00 Very Low Very Low Very Low
fluoxetine 18 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Desipramine 10 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 91.52 High High
Cancer 126 87.04 High High
Depression 95 84.36 Quite High
Tremor 6 80.48 Quite High
Body Weight 9 80.12 Quite High
Anxiety Disorder 33 78.96 Quite High
Suicidal Behaviour 123 75.84 Quite High
Retts Disease 114 70.40 Quite High
Stress 34 64.40 Quite High
Cognitive Disorder 9 55.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EE-induced decrease in mRNA levels for synaptic proteins in Mecp2?
Localization (decrease) of Mecp2
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.07 Pain Relevance 0.08
In addition to a diametrically opposed response of Mecp2?
Localization (response) of Mecp2
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.13 Pain Relevance 0.06
We also observed that the development of paw clasping, a characteristic feature of Mecp2?
Localization (feature) of Mecp2 in paw
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.27 Pain Relevance 0
Thus, if the absence of Mecp2 modified release probability by the mean of a PKA-dependent mechanism, a saturation of presynaptic LTP expression may be expected in adult Mecp2308/Y animals.
Spec (probability) Localization (release) of Mecp2
4) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0.08 Pain Relevance 0.37
In addition, both DNMT1 and methyl-binding proteins (MBP), such as methyl-CpG-binding protein 2 (MeCP2) recruit histone deacetylases which deacetilate histone core tails leading to tighter chromatin packaging, reducing the access of transcriptional factors to DNA [11,12].
Localization (recruit) of MeCP2 in tails
5) Confidence 0.49 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 0.19 Pain Relevance 0
In addition, both DNMT1 and methyl-binding proteins (MBP), such as methyl-CpG-binding protein 2 (MeCP2) recruit histone deacetylases which deacetilate histone core tails leading to tighter chromatin packaging, reducing the access of transcriptional factors to DNA [11,12].
Localization (recruit) of methyl-CpG-binding protein 2 in tails
6) Confidence 0.49 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 0.19 Pain Relevance 0
Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription.177 On the other hand, membrane depolarization causes increased BDNF transcription, which involves dissociation of the MeCP2-histone deacetylase-mSin3A repression complex from its promoter,177,178 which suggests that DNA methylation-related chromatin remodeling is important for activity-dependent Bdnf gene regulation.
Localization (release) of MeCP2 associated with repression
7) Confidence 0.21 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.83 Pain Relevance 0.18

General Comments

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