INT183399

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 18.39
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2b10)
Anatomy Link Frequency
fibroblasts 2
macrophages 1
liver 1
exocrine pancreas 1
lymphocytes 1
Cyp2b10 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 13 98.56 Very High Very High Very High
Paracetamol 2 93.96 High High
headache 11 89.24 High High
Inflammation 94 75.28 Quite High
Eae 2 72.40 Quite High
rheumatoid arthritis 4 58.60 Quite High
cocaine 41 50.00 Quite Low
Inflammatory response 18 46.16 Quite Low
Central nervous system 8 43.52 Quite Low
opiate 3 21.92 Low Low
Disease Link Frequency Relevance Heat
Cancer 930 100.00 Very High Very High Very High
Death 76 100.00 Very High Very High Very High
Apoptosis 65 100.00 Very High Very High Very High
Aging 132 99.96 Very High Very High Very High
Malignant Neoplastic Disease 47 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 268 99.60 Very High Very High Very High
Lymphatic System Cancer 159 99.46 Very High Very High Very High
Meningioma 91 99.46 Very High Very High Very High
Colon Cancer 11 99.36 Very High Very High Very High
Pancreatitis 33 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No differences in the upregulation of cytochrome P450 gene expression (CYP1A2, CYP2B10, CYP3A11 and CYP2E1) were seen following PB or TCPOBOP treatment between NCoA6(PRIP)+/+ or liver NCoA6(PRIP)-/- conditional knockout mice.
Gene_expression (expression) of CYP2B10 in liver associated with targeted disruption
1) Confidence 0.39 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.72 Pain Relevance 0.15
Deletion of the p16INK4a/p14ARF locus or monosomy of chromosome 9 was found in 17% of grade I, 52% of grade II, and 74% of grade III meningiomas (15) resulting in loss of p16 expression (23).
Gene_expression (expression) of p16 associated with monosomy and meningioma
2) Confidence 0.39 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.37 Pain Relevance 0
To that end, demethylation and re-expression of tumor suppressor genes, estrogen receptor, and p16, RAR?
Gene_expression (expression) of p16 associated with cancer
3) Confidence 0.30 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.63 Pain Relevance 0.03
This agent has shown an ability to inhibit DNMT1 gene expression without affecting other DNMTs and to cause demethylation with p16 re-expression in bladder and colon cancer cell lines, as well as to produce tumor growth inhibition in nude mice bearing human lung and colon xenografts [57].
Gene_expression (expression) of p16 in colon associated with cancer and colon cancer
4) Confidence 0.30 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 1.06 Pain Relevance 0
Within this class of so-called "non-toxic and orally administered agents", there is the green tea major polyphenol (-)-epigallocatechin-3-gallate (EGCG) that demonstrated to be an effective DNMT activity inhibitor at micromolar concentrations and that was able to demethylate and reactivate expression of several tumor suppressor genes such as p16, RAR-?
Gene_expression (expression) of p16 associated with cancer
5) Confidence 0.30 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.68 Pain Relevance 0
Furthermore, microarray analysis did not detect increased expression of apoptosis-related genes before, during, or after the peak period of cell death in the exocrine pancreas (P16, 19, and 32; see Additional file 4).
Gene_expression (expression) of P16 in exocrine pancreas associated with apoptosis and death
6) Confidence 0.30 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.86 Pain Relevance 0.07
Despite complex associations between tumor cells and PanINs, histological and molecular evidence suggests that PanINs can gradually progress to PDAC, bearing genetic traits such as Ras mutations, Cyclin D1 overexpression and loss of p16 expression [41,42].
Gene_expression (expression) of p16 associated with adenocarcinoma and cancer
7) Confidence 0.21 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.06 Pain Relevance 0.27
The gene set studied was: p16, RAR?
Gene_expression (was) of p16
8) Confidence 0.18 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 1.12 Pain Relevance 0.09
Employing a more systematic approach, we compared the transcriptional profiles of aged murine stroma measured in this study (considering a false discovery rate of <25% and including those transcripts also found in leukocytes), with previously determined transcriptional profiles of human prostate fibroblasts induced to senesce by different means (H2O2, Bleomycin, replicative senescence, overexpression of p16 and overexpression of oncogenic RAS [11] and unpublished data).
Gene_expression (overexpression) of p16 in fibroblasts associated with aging
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.68 Pain Relevance 0.04
A recent AIDS autopsy study showed that lymph nodes, spleen and brain contained p24 expressing macrophages[21].
Gene_expression (expressing) of p24 in macrophages associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 1.49 Pain Relevance 0
One characteristic of end-stage AIDS is the presence of p24 expressing macrophages along with T cell depletion [8], [9].
Gene_expression (expressing) of p24 in T cell associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 1.40 Pain Relevance 0
Employing a more systematic approach, we compared the transcriptional profiles of aged murine stroma measured in this study (considering a false discovery rate of <25% and including those transcripts also found in leukocytes), with previously determined transcriptional profiles of human prostate fibroblasts induced to senesce by different means (H2O2, Bleomycin, replicative senescence, overexpression of p16 and overexpression of oncogenic RAS [11] and unpublished data).
Gene_expression (overexpression) of p16 in fibroblasts associated with aging
12) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.69 Pain Relevance 0.04
Additionally, previous studies of ARL tissues demonstrated that p24 staining within tumor tissues was predominantly localized to macrophages interspersed in a background of p24-negative lymphocytes.
Gene_expression (staining) of p24 in lymphocytes associated with lymphatic system cancer and cancer
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780293 Disease Relevance 1.48 Pain Relevance 0
These findings support evidence linking altered p16 expression to malignant phenotypes in other types of cancer including breast carcinoma and oropharyngeal squamous cell carcinoma [33, 34].
Gene_expression (expression) of p16 associated with malignant neoplastic disease, cancer, breast cancer and skin cancer
14) Confidence 0.12 Published 2011 Journal Sarcoma Section Body Doc Link PMC3018623 Disease Relevance 1.81 Pain Relevance 0
The role of p16 in mediating radioresistance was demonstrated by experiments that showed that reintroducing p16 expression with a viral vector can increase radiosensitivity in vitro by inciting mitotic catastrophe [35].
Gene_expression (expression) of p16
15) Confidence 0.12 Published 2011 Journal Sarcoma Section Body Doc Link PMC3018623 Disease Relevance 1.70 Pain Relevance 0
Sixteen implanted pups died between P16 and P17 before we could collect 24 h of EEG recording (genotyping showed that they were all KO).
Gene_expression (died) of P16 associated with targeted disruption
16) Confidence 0.11 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.35 Pain Relevance 0.04
This agent has shown an ability to inhibit DNMT1 gene expression without affecting other DNMTs and to cause demethylation with p16 re-expression in bladder and colon cancer cell lines, as well as to produce tumor growth inhibition in nude mice bearing human lung and colon xenografts [57].
Gene_expression (expression) of p16 in lung associated with cancer and colon cancer
17) Confidence 0.10 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 1.06 Pain Relevance 0
Gag was detected using monoclonal anti-p25/24 (ISF2) and anti-p24 (AG 3.0); Nef was stained using anti-HIV-1 IIIB Nef (AE6) and anti-Nef (EH1).


Gene_expression (using) of p24 associated with acquired immune deficiency syndrome or hiv infection
18) Confidence 0.08 Published 2008 Journal The Open Virology Journal Section Body Doc Link PMC2678818 Disease Relevance 0.21 Pain Relevance 0

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