INT18340

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.22
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 16
Total Number 19
Disease Relevance 13.85
Pain Relevance 7.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (CRX)
Anatomy Link Frequency
Visceral 2
ACC 2
vesicles 2
colon 1
rectum 1
CRX (Homo sapiens)
Pain Link Frequency Relevance Heat
Visceral pain 22 100.00 Very High Very High Very High
Analgesic 21 100.00 Very High Very High Very High
antagonist 15 100.00 Very High Very High Very High
adenocard 12 100.00 Very High Very High Very High
Anterior cingulate cortex 9 100.00 Very High Very High Very High
Glutamate 6 100.00 Very High Very High Very High
Central nervous system 12 99.68 Very High Very High Very High
dexamethasone 3 99.04 Very High Very High Very High
Dorsal horn 3 98.56 Very High Very High Very High
nMDA receptor antagonist 3 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 270 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

205 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

22 100.00 Very High Very High Very High
Coronary Heart Disease 12 99.92 Very High Very High Very High
Neurodegenerative Disease 6 99.82 Very High Very High Very High
Nociception 26 99.56 Very High Very High Very High
Neuroleptic Malignant Syndrome 6 98.96 Very High Very High Very High
Stress 54 96.04 Very High Very High Very High
Pain 113 95.52 Very High Very High Very High
Disease 102 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For the CRD experiment, the colorectum was distended once a day for six consecutive days.
Gene_expression (experiment) of CRD
1) Confidence 0.22 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18761632 Disease Relevance 0.32 Pain Relevance 0.46
For histological examination, the rats were killed on the last day of CRD experiment, and haematoxylin and eosin-staining of colon segments was performed.
Gene_expression (experiment) of CRD in colon
2) Confidence 0.22 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18761632 Disease Relevance 0.39 Pain Relevance 0.43
Our results showed that 8 cycles of CRD at 40 mmHg and then 8 cycles at 60 mmHg caused no significant alteration in the architecture of the colonic mucosa compared to naïve controls (Figure 1) in any colonic region examined and confirmed that there was no change in the histological score between control and treated rats (Score?
Gene_expression (cycles) of CRD
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0.21 Pain Relevance 0.42
Though it may be primarily related to the underlying neurodegenerative changes producing CRD described above, other differential diagnostic issues need to be ruled out.
Gene_expression (producing) of CRD associated with neurodegenerative disease
4) Confidence 0.18 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 1.77 Pain Relevance 0
CRD produces a pressor response and contraction of the abdominal and hindlimb musculature (a visceromotor response), both of which are readily quantifiable.
Gene_expression (produces) of CRD in musculature
5) Confidence 0.13 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1971018 Disease Relevance 0.33 Pain Relevance 0.85
Furthermore, the variation in clinical expression with the same mutation in different families [11] and even in the same family with the very surprising asymptomatic homozygote CRD mother, described by Cefalu et al [41], suggests that modifier genes may modulate the transport of the COP II vesicles and that CRD expression is more complex than a simple autosomal recessive disorder.


Gene_expression (expression) of CRD in vesicles associated with disorder of lipid metabolism
6) Confidence 0.12 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 0.70 Pain Relevance 0
Furthermore, the variation in clinical expression with the same mutation in different families [11] and even in the same family with the very surprising asymptomatic homozygote CRD mother, described by Cefalu et al [41], suggests that modifier genes may modulate the transport of the COP II vesicles and that CRD expression is more complex than a simple autosomal recessive disorder.


Gene_expression (expression) of CRD in vesicles associated with disorder of lipid metabolism
7) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 0.76 Pain Relevance 0
This suggests that the recent description of cardiomyopathy in CRD may be related to the tissue-specific expression of abnormal Sar1b protein.
Gene_expression (expression) of CRD associated with coronary heart disease and disorder of lipid metabolism
8) Confidence 0.09 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2956717 Disease Relevance 1.25 Pain Relevance 0
Visceral pain was produced by colorectal distension (CRD) in adult rats.
Gene_expression (produced) of CRD in Visceral associated with visceral pain
9) Confidence 0.09 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20417688 Disease Relevance 0.16 Pain Relevance 0.42
PF could similarly inhibit CRD-evoked p-ERK and c-Fos expression in laminae I-II of the lumbosacral dorsal horn and anterior cingulate cortex (ACC).
Gene_expression (expression) of CRD in ACC associated with dorsal horn and anterior cingulate cortex
10) Confidence 0.07 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.49 Pain Relevance 1.19
PF could also reverse the CRD-evoked increased glutamate concentration by CRD as shown by dynamic microdialysis monitoring in ACC, whereas, DPCPX, an antagonist of adenosine A(1) receptor, significantly blocked the analgesic effect of PF and PF's inhibition on CRD-induced p-ERK and p-CREB expression.
Gene_expression (expression) of CRD in ACC associated with adenocard, glutamate, analgesic, antagonist and anterior cingulate cortex
11) Confidence 0.06 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.46 Pain Relevance 1.29
Results: CRD-induced visceral pain as well as phosphorylated-extracellular signal-regulated protein kinase (p-ERK) and phospho-cAMP response element-binding protein (p-CREB) expression in the CNS structures of NMS rats were suppressed by NMDA receptor antagonist dizocilpine (MK-801) and ERK phosphorylation inhibitor U0126.
Gene_expression (expression) of CRD-induced in CNS associated with nmda receptor antagonist, visceral pain, neuroleptic malignant syndrome and central nervous system
12) Confidence 0.06 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19664651 Disease Relevance 0.55 Pain Relevance 1.08
However, H. pylori expresses several proteins involved in copper export, including the CopA and CopA2 P-type ATPases (Table 1), and the Crd copper resistance determinant (Melchers et al. 1998; Waidner et al. 2002b).
Spec (determinant) Gene_expression (expresses) of Crd
13) Confidence 0.03 Published 2007 Journal Biometals Section Body Doc Link PMC2798029 Disease Relevance 0.14 Pain Relevance 0
Moreover, decreases in expression of CRFR1 in the proximal and distal colon of NS rats following exposure to CRD were blunted in MS rats.
Gene_expression (exposure) of CRD in proximal
14) Confidence 0.03 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.22 Pain Relevance 0.07
Receptor expression was also assessed following exposure to two different acute stressors, the open field (OF) and colorectal distension (CRD).
Gene_expression (expression) of CRD
15) Confidence 0.03 Published 2010 Journal Peptides Section Abstract Doc Link 20096320 Disease Relevance 0.29 Pain Relevance 0.07
Colon stimulation consisted of graded CRD produced by inflating a balloon inside the descending colon and rectum.
Gene_expression (produced) of CRD in descending colon
16) Confidence 0.02 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2518152 Disease Relevance 0 Pain Relevance 0
CRD was produced by rapidly inflating the balloon to the desired pressure (20, 40, 60 or 80 mmHg) for a duration of 10 s.
Gene_expression (produced) of CRD
17) Confidence 0.02 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2518152 Disease Relevance 0 Pain Relevance 0
In contrast, Dex only increased visceral sensitivity at noxious levels of CRD.
Gene_expression (levels) of CRD in visceral associated with dexamethasone
18) Confidence 0.02 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19875699 Disease Relevance 0.67 Pain Relevance 0.83
Colon stimulation consisted of graded CRD produced by inflating a balloon inside the descending colon and rectum.
Gene_expression (produced) of CRD in rectum
19) Confidence 0.01 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2518152 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox