INT183402

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.87
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbx15) DNA binding (Tbx15)
Anatomy Link Frequency
macrophages 2
sciatic nerve 2
neurons 2
brain 2
Tbx15 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 4 99.92 Very High Very High Very High
depression 1 98.92 Very High Very High Very High
Sciatic nerve 11 98.90 Very High Very High Very High
Glutamate receptor 3 98.30 Very High Very High Very High
allodynia 20 96.54 Very High Very High Very High
Hyperalgesia 7 96.26 Very High Very High Very High
Spinal cord 11 95.12 Very High Very High Very High
agonist 19 94.24 High High
Hippocampus 9 91.92 High High
addiction 1 84.36 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 214 99.16 Very High Very High Very High
Nervous System Injury 28 99.04 Very High Very High Very High
Infection 199 99.00 Very High Very High Very High
Depression 1 98.92 Very High Very High Very High
Neuropathic Pain 79 96.54 Very High Very High Very High
Hyperalgesia 10 96.26 Very High Very High Very High
Breast Cancer 55 94.96 High High
Aids-related Complex 70 94.52 High High
Disease 49 90.00 High High
Targeted Disruption 28 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neurotrophin, brain-derived neurotrophic factor (BDNF), is a major
Positive_regulation (-) of Gene_expression (neurotrophic) of de in brain
1) Confidence 0.49 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.54 Pain Relevance 0.19
DNMT3a and DNMT3b have equal preferences for hemi-methylated and non-methylated DNA, and so have been classified as de novo methyltransferases [8].
Positive_regulation (methyltransferases) of Gene_expression (methyltransferases) of de
2) Confidence 0.11 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1131894 Disease Relevance 0.30 Pain Relevance 0
Altogether, we propose a hypothesis for mechanisms of neuropathic hyperalgesia and allodynia after partial sciatic nerve injury (Fig. 6) as follows: 1) intense stimulation of sensory neurons after sciatic nerve injury activates target neurons in the dorsal horn to induce de novo biosynthesis of LPC, which is in turn converted to LPA by ATX/LPLD; 2) LPA is then produced at the dorsal root fibers proximal to the spinal cord.
Positive_regulation (induce) of Gene_expression (biosynthesis) of de novo in sciatic nerve associated with hyperalgesia, nervous system injury, allodynia, neuropathic pain, dorsal horn, sciatic nerve and spinal cord
3) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2365930 Disease Relevance 1.10 Pain Relevance 1.00
The most well-studied relates to metabotropic glutamate receptor-dependent long term depression (mGluR-LTD) in hippocampal CA1 neurons that normally requires de novo protein synthesis in dendrites.
Positive_regulation (requires) of Gene_expression (synthesis) of de novo in neurons associated with depression and glutamate receptor
4) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.86 Pain Relevance 0.32
Strikingly, the rate and number of PMCA cycles required to produce de novo PrPSc was variable in distinct species.
Positive_regulation (required) of Gene_expression (produce) of de novo
5) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2675078 Disease Relevance 0.09 Pain Relevance 0
Transcription of the IL-12p40 gene in macrophages requires de novo protein synthesis during the inducing HSV infection, which could explain the relatively late appearance of IL-12 production [238,367].
Positive_regulation (requires) of Gene_expression (synthesis) of de novo in macrophages associated with cold sores and infection
6) Confidence 0.01 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.12 Pain Relevance 0.08
In MDA-MB231 cells, 15dPGJ2 increased expression of p21Waf1/Cip1, p27Kip1, and other de novo gene expressions [44].
Positive_regulation (increased) of Gene_expression (expression) of de novo
7) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.86 Pain Relevance 0.03

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