INT18343

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Context Info
Confidence 0.13
First Reported 1985
Last Reported 1990
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.18
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 2
Fam13a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 32 100.00 Very High Very High Very High
Opioid 10 99.98 Very High Very High Very High
Analgesic 2 99.34 Very High Very High Very High
opioid receptor 2 94.72 High High
analgesia 2 91.44 High High
agonist 4 90.36 High High
narcan 4 87.52 High High
Spinal cord 4 87.44 High High
opiate 2 80.96 Quite High
tolerance 2 79.44 Quite High
Disease Link Frequency Relevance Heat
Catatonia 2 90.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results strongly suggest the existence of at least three components of non-mu, non-delta [3H]bremazocine binding in the rat brain: two with differential affinity for dynorphin A1-13 and U69-593 (kappa-1 and kappa-2 sites), and a third (termed here R1) that was further resolved into two binding sites by bremazocine.
A1-13 Binding (binding) of in brain associated with dynorphin
1) Confidence 0.13 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1971019 Disease Relevance 0 Pain Relevance 0.58
Characterization of kappa opioid binding using dynorphin A1-13 and U69,593 in the rat brain.
A1-13 Binding (binding) of in brain associated with dynorphin, analgesic and opioid
2) Confidence 0.13 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1971019 Disease Relevance 0 Pain Relevance 0.58
The rats dose-dependently generalized the effects of intracerebroventricularly injected ethylketocyclazocine but not beta-endorphin, alpha-neoendorphin, dynorphin A1-8, dynorphin A1-13, D-Cys2-L-Cys5-dynorphin A1-13 or dynorphin A.
A1-13 Neg (not) Binding (generalized) of associated with dynorphin
3) Confidence 0.11 Published 1985 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2862651 Disease Relevance 0.09 Pain Relevance 1.02
The rats dose-dependently generalized the effects of intracerebroventricularly injected ethylketocyclazocine but not beta-endorphin, alpha-neoendorphin, dynorphin A1-8, dynorphin A1-13, D-Cys2-L-Cys5-dynorphin A1-13 or dynorphin A.
A1-13 Neg (not) Binding (generalized) of associated with dynorphin
4) Confidence 0.11 Published 1985 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2862651 Disease Relevance 0.09 Pain Relevance 1.01

General Comments

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