INT183467

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 9.89
Pain Relevance 5.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
Anatomy Link Frequency
leukocyte 2
eosinophils 1
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 555 99.92 Very High Very High Very High
cINOD 213 99.50 Very High Very High Very High
COX-2 inhibitor 19 98.16 Very High Very High Very High
fibrosis 7 98.16 Very High Very High Very High
dexamethasone 20 97.28 Very High Very High Very High
aspirin 54 97.08 Very High Very High Very High
qutenza 48 96.32 Very High Very High Very High
cytokine 78 96.28 Very High Very High Very High
Inflammatory stimuli 35 92.96 High High
Pain 134 92.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 654 99.92 Very High Very High Very High
Cancer 90 99.70 Very High Very High Very High
Nociception 18 99.60 Very High Very High Very High
Apoptosis 15 99.50 Very High Very High Very High
Cystic Fibrosis 6 98.16 Very High Very High Very High
Pain 134 92.08 High High
Adhesions 24 91.44 High High
Pressure And Volume Under Development 26 89.72 High High
Colitis 6 89.60 High High
Neurodegenerative Disease 12 88.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein inhibitor of NF-kB (IkBa) aims at retrieving nuclear concentration of NF-kB with the formation of an inactive complex in the cytoplasm regulating the expression of various inflammatory genes.
Negative_regulation (inhibitor) of NF-kB associated with inflammation
1) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.55 Pain Relevance 0.35
activated eosinophils by blocking NF-kB (genomic mechanism).
Negative_regulation (blocking) of NF-kB in eosinophils
2) Confidence 0.07 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.46 Pain Relevance 0.45
Results of a study by Zandi and Karin suggested that curcumin might be efficacious in the treatment of cystic fibrosis because of its anti-inflammatory effect.[121] Curcumin is known to inhibit inflammation by suppressing NF-kB, restricting various activators of NF-kB as well as stemming its expression.
Negative_regulation (suppressing) of NF-kB associated with fibrosis, inflammation and cystic fibrosis
3) Confidence 0.06 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.34 Pain Relevance 0.56
In vitro inhibition of COX-2 with targeted molecules is thought to promote apoptosis of cancer cells through inhibition of NF-kB activation [20].
Negative_regulation (inhibition) of NF-kB associated with cancer and apoptosis
4) Confidence 0.06 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234426 Disease Relevance 1.15 Pain Relevance 0.38
It also inhibits NF-kB, thus producing an anti-inflammatory effect.
Negative_regulation (inhibits) of NF-kB associated with inflammation
5) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.35 Pain Relevance 1.03
In addition to the COX pathway, many natural compounds act to inhibit nuclear factor-kB (NF-kB) inflammatory pathways.


Negative_regulation (inhibit) of NF-kB associated with inflammation
6) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.26 Pain Relevance 0.84
These agents inhibit the NF-kB pathway in endothelial cells and block NF-kB activation to inhibit leukocyte recruitment.[114115116] NSAIDs have also been found to inhibit both the COX system and the NF-kB pathway.
Negative_regulation (inhibit) of NF-kB in leukocyte associated with cinod
7) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.80 Pain Relevance 0.65
Resveratrol shows the anti-inflammatory properties as it suppresses COX-2 by blocking NF-kB activation.
Negative_regulation (blocking) of NF-kB associated with inflammation
8) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.82 Pain Relevance 0.33
These agents inhibit the NF-kB pathway in endothelial cells and block NF-kB activation to inhibit leukocyte recruitment.[114115116] NSAIDs have also been found to inhibit both the COX system and the NF-kB pathway.
Negative_regulation (inhibit) of NF-kB in leukocyte associated with cinod
9) Confidence 0.04 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.90 Pain Relevance 0.69
signaling [41] and decreased NF-kB signaling [42].
Negative_regulation (decreased) of NF-kB
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928273 Disease Relevance 0.59 Pain Relevance 0.13
At our institution, we are evaluating the combination of erlotinib with inhibitors of the Akt/ NF-kB.Combining EGFR blockade with non-gemcitabine based cytotoxic agents such as docetaxel or ixabepilone.Combining erlotinib with radiation.
Negative_regulation (inhibitors) of NF-kB
11) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.67 Pain Relevance 0

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