INT183468

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.35
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TBK1) plasma membrane (TBK1) cytoplasm (TBK1)
Anatomy Link Frequency
nucleus 1
eosinophils 1
TBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 99.98 Very High Very High Very High
Inflammation 271 99.36 Very High Very High Very High
dexamethasone 20 99.30 Very High Very High Very High
aspirin 18 93.92 High High
metalloproteinase 12 89.32 High High
cINOD 71 78.00 Quite High
Pain 44 72.60 Quite High
withdrawal 3 67.44 Quite High
cva 6 61.44 Quite High
fibrosis 31 56.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 345 99.36 Very High Very High Very High
Death 31 98.00 Very High Very High Very High
Injury 18 97.52 Very High Very High Very High
Apoptosis 55 94.08 High High
Arthropathy 4 92.92 High High
Disease 36 89.76 High High
Cancer 103 85.44 High High
Adhesions 15 75.84 Quite High
Pain 44 72.60 Quite High
Stress 15 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF pathway group (19 transcripts): TNF, TNFSF10, TNFSF14, TNFRSF1A, TNFRSF1B, TNFRSF10B, CD27, CD40, LTBR, TNFAIP3, TRAF2, TRAF3, TRADD, TBK1, FADD, CFLAR, RIPK1, RIPK2, and MAP3K1, B.
Localization (group) of TBK1
1) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.23 Pain Relevance 0.15
The dynamics of nuclear concentration of NF-kB are modeled in (2b) assuming NFkBn as a percentage of its total cytoplasmic concentration.
Localization (concentration) of NF-kB
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.27 Pain Relevance 0.14
Dexamethasone, as other GCS, inhibits cytokines release by eosinophils by interference with transcription factors such as NF-kB and AP-1 [9].
Localization (release) of NF-kB in eosinophils associated with dexamethasone and cytokine
3) Confidence 0.12 Published 2005 Journal Clin Mol Allergy Section Body Doc Link PMC1131914 Disease Relevance 0.47 Pain Relevance 0.44
A variety of provoking stimuli can degrade the IkB and result in the nuclear translocation of NF-kB to be free to activate DNA synthesis of inflammatory cytokines [Figure 2].
Localization (translocation) of NF-kB associated with inflammation and cytokine
4) Confidence 0.08 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 0.97 Pain Relevance 0.78
The NF-kB proteins are localized in the cytoplasm of the cell and are associated with a family of inhibitory proteins known as inhibitor of kB (IkB).[43119] The TNF-?
Localization (localized) of NF-kB
5) Confidence 0.08 Published 2010 Journal Surgical Neurology International Section Body Doc Link PMC3011108 Disease Relevance 1.21 Pain Relevance 0.83
, leading to the destruction of I-kB and the entry of NF-kB into the nucleus [31-33].
Localization (entry) of NF-kB in nucleus
6) Confidence 0.04 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.41 Pain Relevance 0.03
of IkB, induction of TSC22, NF-kB, GADD153, PTEN, etc.) may depend on the
Localization (etc.) of NF-kB
7) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.79 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox