INT183479

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 0.91
Pain Relevance 4.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 3
plasma 2
cortex 1
Slc6a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 824 100.00 Very High Very High Very High
Kinase C 165 100.00 Very High Very High Very High
addiction 32 92.40 High High
Opioid 3 91.96 High High
tolerance 7 91.32 High High
alcohol 3 90.92 High High
cocaine 23 89.80 High High
imagery 28 74.92 Quite High
Catecholamine 15 74.00 Quite High
Neurotransmitter 28 71.44 Quite High
Disease Link Frequency Relevance Heat
Body Weight 14 95.28 Very High Very High Very High
Opiate Addiction 3 92.40 High High
Apoptosis 3 84.72 Quite High
Drug Dependence 28 79.20 Quite High
Congenital Anomalies 11 70.72 Quite High
Gliosis 10 56.56 Quite High
Manic Depressive Disorder 3 51.92 Quite High
Diabetes Mellitus 18 51.68 Quite High
Depression 5 51.08 Quite High
Attention Deficit Hyperactivity Disorder 3 50.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the increased surface expression of DAT by CPE may involve phosphorylation events.
Positive_regulation (increased) of Gene_expression (expression) of DAT
1) Confidence 0.57 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.12
As described in Fig. 2B, DAT-CT tail583–620 MG cotransfected with DAT alone did not change either the Km or Vmax of cellular [3H] DA uptake.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of DAT associated with dopamine
2) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.26
Coexpression of CPE with DAT changed the diffuse DAT expression throughout the cell to stronger plasma membrane localization and suggests the interaction occur intracellularlly.
Positive_regulation (diffuse) of Gene_expression (expression) of DAT in plasma
3) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.08
In addition, immunofluorescence analysis demonstrated that co-expression of CPE and DAT facilitated surface translocation of both proteins.
Positive_regulation (facilitated) of Gene_expression (expression) of DAT
4) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
Functional changes caused by CPE could be attributed to enhanced DAT expression and subsequent increase in DAT cell surface localization, due to decreased DAT degradation.
Positive_regulation (enhanced) of Gene_expression (expression) of DAT
5) Confidence 0.38 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.15
The present finding highlighted the importance of CPE in trafficking and metabolic processing of DAT.
Positive_regulation (importance) of Gene_expression (processing) of DAT
6) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.12
As described in Fig. 2B, DAT-CT tail583–620 MG cotransfected with DAT alone did not change either the Km or Vmax of cellular [3H] DA uptake.
Positive_regulation (cotransfected) of Gene_expression (cotransfected) of DAT associated with dopamine
7) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.26
The cell surface and total expression of DAT was presented as the colorimetric readings under nonpermeabilized and permeabilized conditions and then normalized to the control groups (transfected with DAT alone) respectively.


Positive_regulation (transfected) of Gene_expression (transfected) of DAT
8) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0
However, there have been reports that PKC-induced phosphorylation of the DAT itself is not required for PKC-induced DAT sequestration [56], leading to the possibility that DAT are trapped in its phosphorylated state in subcellular compartment, where CPE may speed up the assorting and recycling back to the membrane of the internalized DAT.
Neg (not) Positive_regulation (required) of Gene_expression (sequestration) of DAT associated with kinase c
9) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.26
As shown in Fig 3, coexpression of CPE increased the levels of both total DAT and cell surface DAT to about ~20% (Fig. 3A, B).
Positive_regulation (increased) of Gene_expression (levels) of DAT
10) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
As shown in Fig 3, coexpression of CPE increased the levels of both total DAT and cell surface DAT to about ~20% (Fig. 3A, B).
Positive_regulation (increased) of Gene_expression (levels) of DAT
11) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.18
M/125 nl) almost fully restored to control levels the rate and the amount of AMPH-evoked DA release (Figure 6A and 6B), as well as the rate of DAT-mediated clearance (Figure 6C).
Positive_regulation (restored) of Gene_expression (clearance) of DAT-mediated associated with dopamine
12) Confidence 0.35 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.13 Pain Relevance 0.36
The mechanism underlying the regulation of DA clearance by PI3K seems to rely on DAT trafficking, as Garcia et al. [13] and Wei et al. [29] recently demonstrated that Akt activity is critical for sustaining human DAT (hDAT) membrane expression and function.
Positive_regulation (critical) of Gene_expression (expression) of hDAT associated with dopamine
13) Confidence 0.33 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.33 Pain Relevance 0.67
This observation has been explained with the NAT capacity to totally compensate for DAT exclusion, due to the high affinity of DA for NAT [17,18].
Positive_regulation (compensate) of Gene_expression (exclusion) of DAT associated with dopamine
14) Confidence 0.31 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1134661 Disease Relevance 0 Pain Relevance 0.67
PI3K signaling, which is stimulated by activation of IRs and other RTKs [23], plays a critical role in the maintenance of DA clearance and DAT cell surface expression [11,13,21,35].
Positive_regulation (maintenance) of Gene_expression (expression) of DAT associated with dopamine
15) Confidence 0.29 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.37
The present experiments demonstrated that (1) extended access to METH self-administration was associated with a progressive escalation of drug intake by rats and significant decreases in their body weights; (2) this pattern of METH intake resulted in persistent dose-dependent depletion of striatal and cortical DA levels measured at various times after cessation of drug treatment; (3) METH self-administration also caused decreases in the expression of striatal and cortical TH and DAT proteins; and (4) METH induced dose-dependent increases in GFAP expression in both, striatum and cortex.
Positive_regulation (induced) of Gene_expression (expression) of DAT in striatum associated with dopamine and body weight
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.22 Pain Relevance 0.13
The present experiments demonstrated that (1) extended access to METH self-administration was associated with a progressive escalation of drug intake by rats and significant decreases in their body weights; (2) this pattern of METH intake resulted in persistent dose-dependent depletion of striatal and cortical DA levels measured at various times after cessation of drug treatment; (3) METH self-administration also caused decreases in the expression of striatal and cortical TH and DAT proteins; and (4) METH induced dose-dependent increases in GFAP expression in both, striatum and cortex.
Positive_regulation (induced) of in cortex Gene_expression (expression) of DAT in striatum associated with dopamine and body weight
17) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808335 Disease Relevance 0.22 Pain Relevance 0.13

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