INT183536

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.70
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fibroblasts 1
lymphoblasts 1
SNORD109A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 20 81.68 Quite High
tolerance 16 81.36 Quite High
Serotonin 2 79.32 Quite High
Neurobehavioral 12 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Pain threshold 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 324 98.36 Very High Very High Very High
Macrocephaly 4 84.24 Quite High
Hypersomnia 12 83.32 Quite High
Pain 22 81.68 Quite High
Obesity 64 78.56 Quite High
Growth Problems 16 77.76 Quite High
Reprotox - General 2 8 77.16 Quite High
Muscle Hypotonia 28 75.56 Quite High
Sprains And Strains 14 71.36 Quite High
Hyperphagia 60 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the human genome, there are two copies of SNORD109 (HBII-438), one located upstream of SNORD116 (SNORD109A, GeneID: 338428) and the other downstream of SNORD115 (SNORD109B, GeneID: 338429).
Gene_expression (one) of SNORD109A
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.69 Pain Relevance 0.04
In the human genome, there are two copies of SNORD109 (HBII-438), one located upstream of SNORD116 (SNORD109A, GeneID: 338428) and the other downstream of SNORD115 (SNORD109B, GeneID: 338429).
Gene_expression (copies) of SNORD109
2) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248623 Disease Relevance 0.63 Pain Relevance 0.04
There are two multi-copy snoRNA clusters (HBII-52 and PWCR1/HBII-85) [21,22], three single copy snoRNA genes (HBII-436, HBII-13, and HBII-437), and one snoRNA gene (HBII-438) present in two copies that are 240 kb apart [19].
Gene_expression (present) of HBII-438
3) Confidence 0.36 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1142316 Disease Relevance 0.12 Pain Relevance 0
When testing for the intron-encoded C/D box snoRNAs, we were able to document expression of HBII-13 and HBII-437 and lack of expression for HBII-438A/B and HBII-85/PWCR1 (Fig. 7).
Gene_expression (expression) of HBII-438A
4) Confidence 0.36 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1142316 Disease Relevance 0.14 Pain Relevance 0
By RT-PCR of lymphoblasts and fibroblasts, we find that upstream SNURF/SNRPN exons and snoRNAs HBII-437 and HBII-13 are expressed, but the downstream snoRNAs PWCR1/HBII-85 and HBII-438A/B snoRNAs are not.


Gene_expression (expressed) of HBII-438A in fibroblasts
5) Confidence 0.16 Published 2005 Journal BMC Med Genet Section Abstract Doc Link PMC1142316 Disease Relevance 0.56 Pain Relevance 0.12
By RT-PCR of lymphoblasts and fibroblasts, we find that upstream SNURF/SNRPN exons and snoRNAs HBII-437 and HBII-13 are expressed, but the downstream snoRNAs PWCR1/HBII-85 and HBII-438A/B snoRNAs are not.


Gene_expression (expressed) of HBII-438A in lymphoblasts
6) Confidence 0.05 Published 2005 Journal BMC Med Genet Section Abstract Doc Link PMC1142316 Disease Relevance 0.56 Pain Relevance 0.12

General Comments

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