INT183555

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.61
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fibroblasts 1
lymphoblasts 1
SNORD108 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 82.68 Quite High
tolerance 10 82.36 Quite High
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Macrocephaly 5 85.24 High High
Syndrome 185 84.80 Quite High
Hypersomnia 15 84.32 Quite High
Pain 10 82.68 Quite High
Obesity 20 79.56 Quite High
Growth Problems 10 78.76 Quite High
Reprotox - General 2 10 78.16 Quite High
Muscle Hypotonia 15 76.56 Quite High
Uniparental Disomy 10 48.00 Quite Low
Disease 10 47.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As for the intron-encoded C/D box snoRNAs, HBII-13 and HBII-437 were expressed, and HBII-438A/B and HBII-85/PWCR1 were not.
Gene_expression (expressed) of HBII-437
1) Confidence 0.44 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1142316 Disease Relevance 0.22 Pain Relevance 0
There are two multi-copy snoRNA clusters (HBII-52 and PWCR1/HBII-85) [21,22], three single copy snoRNA genes (HBII-436, HBII-13, and HBII-437), and one snoRNA gene (HBII-438) present in two copies that are 240 kb apart [19].
Gene_expression (present) of HBII-437
2) Confidence 0.34 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1142316 Disease Relevance 0.13 Pain Relevance 0
When testing for the intron-encoded C/D box snoRNAs, we were able to document expression of HBII-13 and HBII-437 and lack of expression for HBII-438A/B and HBII-85/PWCR1 (Fig. 7).
Gene_expression (expression) of HBII-437
3) Confidence 0.34 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1142316 Disease Relevance 0.14 Pain Relevance 0
By RT-PCR of lymphoblasts and fibroblasts, we find that upstream SNURF/SNRPN exons and snoRNAs HBII-437 and HBII-13 are expressed, but the downstream snoRNAs PWCR1/HBII-85 and HBII-438A/B snoRNAs are not.


Gene_expression (expressed) of HBII-437 in fibroblasts
4) Confidence 0.34 Published 2005 Journal BMC Med Genet Section Abstract Doc Link PMC1142316 Disease Relevance 0.57 Pain Relevance 0.12
By RT-PCR of lymphoblasts and fibroblasts, we find that upstream SNURF/SNRPN exons and snoRNAs HBII-437 and HBII-13 are expressed, but the downstream snoRNAs PWCR1/HBII-85 and HBII-438A/B snoRNAs are not.


Gene_expression (expressed) of HBII-437 in lymphoblasts
5) Confidence 0.11 Published 2005 Journal BMC Med Genet Section Abstract Doc Link PMC1142316 Disease Relevance 0.57 Pain Relevance 0.12

General Comments

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