INT183560

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.59
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GABRB3) transport (GABRB3) plasma membrane (GABRB3)
transmembrane transport (GABRB3)
Anatomy Link Frequency
brain 2
GABRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 38 99.80 Very High Very High Very High
Neurotransmitter 38 99.14 Very High Very High Very High
addiction 46 98.56 Very High Very High Very High
gABA 248 98.32 Very High Very High Very High
Gabapentin 45 98.30 Very High Very High Very High
Cannabinoid receptor 71 97.28 Very High Very High Very High
substance P 29 94.64 High High
GABAergic 357 94.08 High High
agonist 48 93.52 High High
dopamine receptor 9 91.72 High High
Disease Link Frequency Relevance Heat
Alcohol Addiction 36 98.88 Very High Very High Very High
Dysphagia 93 98.56 Very High Very High Very High
Disease 24 93.60 High High
Sleep Initiation And Maintenance Disorders 87 92.24 High High
Drug Dependence 23 88.28 High High
Cataract 5 85.12 High High
Generalized Anxiety Disorder 24 85.08 High High
Lifespan 136 83.44 Quite High
Schizophrenia 33 82.36 Quite High
Cognitive Disorder 23 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preliminary FISH analysis showed that the breakpoint in 15q11 was located between D15S11 and GABRB3, which flank the SNRPN locus (data not shown).
GABRB3 Binding (flank) of
1) Confidence 0.23 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1142316 Disease Relevance 0.06 Pain Relevance 0
Eszopiclone acts by binding to the GABAA receptor.
GABAA receptor Binding (binding) of
2) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Abstract Doc Link PMC2655082 Disease Relevance 0.20 Pain Relevance 0
Additionally, a GABAA receptor gene within this cluster was found to be associated with a DSM-IV diagnosis of alcohol dependence [43].
GABAA receptor gene Binding (associated) of associated with addiction and alcohol
3) Confidence 0.13 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2851592 Disease Relevance 0.44 Pain Relevance 0.36
It was synthesized as a structural analog of GABA, which is a well-known inhibitory neurotransmitter in the brain, with the hope that it would penetrate into the brain and have a GABA-mimetic effect.14 The mechanism of action of gabapentin is not yet fully understood, and there is no convincing evidence to suggest that it interacts with GABAA or GABAB receptors.
GABAA Binding (interacts) of in brain associated with neurotransmitter, gaba and gabapentin
4) Confidence 0.09 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2987504 Disease Relevance 0.29 Pain Relevance 1.10
0.20; GABAA?
GABAA Binding (0.20) of
5) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.13 Pain Relevance 0.32
If ocular dominance plasticity follows the development of GABAA?
GABAA Binding (development) of
6) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.41 Pain Relevance 0.11
0.04; GABAA?
GABAA Binding (0.04) of
7) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.14 Pain Relevance 0.32
0.25; GABAA?
GABAA Binding (0.25) of
8) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.14 Pain Relevance 0.32
There was initially more GABAA?
GABAA Binding (initially) of
9) Confidence 0.08 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.13 Pain Relevance 0.04
-Actin mAb from Sigma, goat anti-GABAA receptor-?
GABAA Binding (receptor) of
10) Confidence 0.04 Published 2008 Journal Biological Procedures Online Section Body Doc Link PMC2683550 Disease Relevance 0.15 Pain Relevance 0.41
Ethanol also acts in the CNS binding to the GABAA receptor and alcohol ingestion can predispose to oropharyngeal aspiration [64].
GABAA receptor Binding (binding) of associated with alcohol
11) Confidence 0.02 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929516 Disease Relevance 0.50 Pain Relevance 0.19
GABA is the major inhibitory neurotransmitter in the brain, and it exerts its action by interacting with three types of receptor (GABAA, GABAB, and GABAC).
GABAA Binding (interacting) of in brain associated with neurotransmitter and gaba
12) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0 Pain Relevance 0.62

General Comments

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