INT183568

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
Spinal 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 83 100.00 Very High Very High Very High
Glutamate 10 99.92 Very High Very High Very High
Dorsal horn neuron 5 94.96 High High
Glutamate receptor 14 94.64 High High
Spinal cord 24 92.36 High High
agonist 2 92.00 High High
nMDA receptor 5 83.36 Quite High
withdrawal 43 79.48 Quite High
Hyperalgesia 28 50.00 Quite Low
antagonist 19 40.24 Quite Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 4 98.16 Very High Very High Very High
Hypertrophy 8 89.68 High High
Targeted Disruption 8 88.56 High High
Cv General 4 Under Development 10 85.52 High High
Emphysema 27 76.44 Quite High
Cv Unclassified Under Development 1 65.16 Quite High
Right Ventricular Hypertrophy 29 57.20 Quite High
Acid Reflux 1 53.88 Quite High
Hypertension 8 51.96 Quite High
Hyperalgesia 28 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal activation of PKC increases release of glutamate in vivo [9] and in vitro [12], and formalin-induced release of glutamate is prevented by blockade of PKC [17].
Negative_regulation (prevented) of Protein_catabolism (blockade) of PKC in Spinal associated with glutamate and kinase c
1) Confidence 0.36 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0 Pain Relevance 1.33
In contrast, a high degree of PKC ?
Negative_regulation (high) of Protein_catabolism (degree) of PKC
2) Confidence 0.05 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1142330 Disease Relevance 1.12 Pain Relevance 0

General Comments

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