INT18357

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2011
Negated 14
Speculated 31
Reported most in Abstract
Documents 825
Total Number 856
Disease Relevance 307.11
Pain Relevance 382.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
neurons 51
nerve 44
sensory neurons 40
embryonic kidney 36
keratinocytes 28
TRPV1 (Homo sapiens)
TRPV1 - L549M (1)
Pain Link Frequency Relevance Heat
qutenza 6009 100.00 Very High Very High Very High
Pain 3645 100.00 Very High Very High Very High
Inflammation 1761 100.00 Very High Very High Very High
agonist 1397 100.00 Very High Very High Very High
TRP channel 726 100.00 Very High Very High Very High
antagonist 723 100.00 Very High Very High Very High
dorsal root ganglion 654 100.00 Very High Very High Very High
nociceptor 623 100.00 Very High Very High Very High
substance P 544 100.00 Very High Very High Very High
bradykinin 520 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 3400 100.00 Very High Very High Very High
INFLAMMATION 1842 100.00 Very High Very High Very High
Ganglion Cysts 1219 100.00 Very High Very High Very High
Nociception 936 100.00 Very High Very High Very High
Cough 712 100.00 Very High Very High Very High
Hyperalgesia 518 100.00 Very High Very High Very High
Injury 771 99.98 Very High Very High Very High
Diabetic Neuropathy 345 99.98 Very High Very High Very High
Cancer 123 99.96 Very High Very High Very High
Neuroblastoma 28 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we investigated the effect of acute UV irradiation on TRPV1 expression in human skin and the changes in TRPV1 mRNA and protein in intrinsic ageing and photoageing using human sun-protected (upper inner arm) and sun-exposed (forearm) skin of young and elderly subjects.
Gene_expression (expression) of TRPV1 in forearm associated with aging
1) Confidence 0.78 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.19 Pain Relevance 0.09
Based on the above results, our data suggest that the expression of TRPV1 is affected by both the intrinsic ageing and photoageing processes.
Gene_expression (expression) of TRPV1 associated with aging
2) Confidence 0.78 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.21 Pain Relevance 0
Increased expression of TRPV1 channel in intrinsically aged and photoaged human skin in vivo.
Gene_expression (expression) of TRPV1 in skin
3) Confidence 0.78 Published 2009 Journal Exp. Dermatol. Section Title Doc Link 19161409 Disease Relevance 0.17 Pain Relevance 0.09
TRPV1 protein was expressed at higher levels by 2.6-fold in the sun-protected skin of the elderly subjects than in that of young people according to western blotting, real-time PCR analysis and immunohistochemical staining.
Gene_expression (expressed) of TRPV1 protein in skin
4) Confidence 0.78 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.16 Pain Relevance 0.07
Western blot analysis of UV-irradiated young buttock skin revealed that the expression of TRPV1 protein was increased at 24 h (2.3-fold) and 48 h (2.4-fold) after UV irradiation.
Gene_expression (expression) of TRPV1 protein in skin
5) Confidence 0.78 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.18 Pain Relevance 0.08
Also, we found increased expression of TRPV1 in nerve fibres of elderly persons using double staining of TRPV1 and nerve fibres.
Gene_expression (expression) of TRPV1 in nerve
6) Confidence 0.78 Published 2009 Journal Exp. Dermatol. Section Abstract Doc Link 19161409 Disease Relevance 0.13 Pain Relevance 0.05
Increased expression of TRPV1 in squamous cell carcinoma of the human tongue.
Gene_expression (expression) of TRPV1 in tongue associated with skin cancer
7) Confidence 0.78 Published 2009 Journal Oral Dis Section Title Doc Link 19320840 Disease Relevance 0.19 Pain Relevance 0.09
METHODS: Immunohistochemistry, Western blotting and quantitative 'real-time' Q-PCR were performed to define the expression of TRPV1.
Gene_expression (expression) of TRPV1
8) Confidence 0.78 Published 2009 Journal Oral Dis Section Body Doc Link 19320840 Disease Relevance 0.28 Pain Relevance 0
Furthermore, statistical analysis revealed that the marked overexpression of TRPV1 found in all grades of SCC showed no correlation with the degree of malignancy of the tumours.
Gene_expression (overexpression) of TRPV1
9) Confidence 0.78 Published 2009 Journal Oral Dis Section Body Doc Link 19320840 Disease Relevance 0.24 Pain Relevance 0
Finally, the molecular expression of TRPV1 was also identified in an SCC-derived cell line and was shown to be increased in parallel with the accelerated growth of the cells.
Gene_expression (expression) of TRPV1
10) Confidence 0.78 Published 2009 Journal Oral Dis Section Body Doc Link 19320840 Disease Relevance 0.22 Pain Relevance 0
In this study, we have investigated the molecular expression of TRPV1 in the human tongue and its high-incidence malignant (squamous cell carcinoma, SCC) and premalignant (leukoplakia) conditions.
Spec (investigated) Gene_expression (expression) of TRPV1 in tongue associated with malignant neoplastic disease, leukoplakia and skin cancer
11) Confidence 0.78 Published 2009 Journal Oral Dis Section Abstract Doc Link 19320840 Disease Relevance 0.46 Pain Relevance 0.09
Using Ca(2+) imaging on TRPV1 receptors heterologously expressed in the human embryonic kidney (HEK) 293 cells and on dissociated primary sensory neurons, we find that in both systems, AS activate TRPV1 receptors, and, moreover, they sensitize these channels to acid and heat.
Gene_expression (expressed) of TRPV1 in embryonic kidney associated with imagery
12) Confidence 0.78 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17567713 Disease Relevance 0.25 Pain Relevance 0.05
The actions of sulfhydryl modifiers on heat-evoked whole-cell membrane currents were examined in TRPV1-transfected human embryonic kidney 293T cells.
Spec (examined) Gene_expression (transfected) of TRPV1 in embryonic kidney
13) Confidence 0.78 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16614139 Disease Relevance 0 Pain Relevance 0
Increased TRPV1 expression in the inflamed oesophagus may mediate the heartburn in oesophagitis, and TRPV1 blockers may provide novel treatment.


Gene_expression (expression) of TRPV1 in oesophagus
14) Confidence 0.78 Published 2004 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 15316415 Disease Relevance 0.05 Pain Relevance 0
Six such compounds were synthesized and tested for calcium mobilization at recombinant TRPV1 receptors overexpressed in HEK293 cells.
Gene_expression (overexpressed) of TRPV1
15) Confidence 0.78 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17616464 Disease Relevance 0 Pain Relevance 0.09
Studies with animals that are deficient in the vanilloid (capsaicin) receptor TRPV1 have confirmed the pivotal role that TRPV1 has in the development of post-inflammatory hyperalgesia, and enhanced TRPV1 expression has been described in various human disorders.
Gene_expression (expression) of TRPV1 associated with hyperalgesia, inflammation and qutenza
16) Confidence 0.78 Published 2005 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 16043235 Disease Relevance 0.20 Pain Relevance 0.39
A series of novel 4-oxopyrimidine TRPV1 antagonists was evaluated in assays measuring the blockade of capsaicin or acid-induced influx of calcium into CHO cells expressing TRPV1.
Gene_expression (expressing) of TRPV1 associated with qutenza and antagonist
17) Confidence 0.78 Published 2007 Journal J. Med. Chem. Section Abstract Doc Link 17585750 Disease Relevance 0 Pain Relevance 0.32
Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner.
Gene_expression (express) of TRPV1 in skin associated with qutenza, acne and agonist
18) Confidence 0.78 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 18769453 Disease Relevance 0.60 Pain Relevance 0.33
Transient receptor potential vanilloid-1 (TRPV1), originally described as a central integrator of nociception, is expressed on human epidermal and hair follicle keratinocytes and is involved in regulation of cell growth and death.
Gene_expression (expressed) of TRPV1 in keratinocytes associated with nociception and death
19) Confidence 0.78 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 18769453 Disease Relevance 0.39 Pain Relevance 0.08
Transient receptor potential vanilloid-1 (TRPV1), originally described as a central integrator of nociception, is expressed on human epidermal and hair follicle keratinocytes and is involved in regulation of cell growth and death.
Gene_expression (expressed) of vanilloid-1 in keratinocytes associated with nociception and death
20) Confidence 0.78 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 18769453 Disease Relevance 0.39 Pain Relevance 0.08

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