INT18360

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Context Info
Confidence 0.32
First Reported 1973
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.07
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
leukocytes 1
luteal cell 1
adipocytes 1
body 1
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 78 99.98 Very High Very High Very High
Paracetamol 2 99.22 Very High Very High Very High
antagonist 4 98.66 Very High Very High Very High
agonist 13 98.08 Very High Very High Very High
Pain 4 98.04 Very High Very High Very High
cINOD 7 97.84 Very High Very High Very High
cytokine 20 97.00 Very High Very High Very High
COX-2 inhibitor 3 96.32 Very High Very High Very High
methadone 1 94.88 High High
cva 1 94.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 90 99.98 Very High Very High Very High
Malaria 60 99.96 Very High Very High Very High
Neurodegenerative Disease 1 99.84 Very High Very High Very High
Obesity 102 98.84 Very High Very High Very High
Premature Birth 4 98.80 Very High Very High Very High
Pain 4 98.04 Very High Very High Very High
Birth Weight 46 97.80 Very High Very High Very High
Fever 6 97.80 Very High Very High Very High
Multiple Sclerosis 132 97.40 Very High Very High Very High
Eclampsia 6 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A major drawback of the current therapeutic strategies aiming at controlling PGs is that they aim at early steps of biosynthesis thus blocking all PGs, good and bad.
Regulation (controlling) of PGs
1) Confidence 0.32 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18802217 Disease Relevance 0.42 Pain Relevance 0.21
The most important first step is oxidation of the 15-hydroxyl group to a carbonyl, which modifies the activities of PGs and allows further degradation and elimination via urine; this series of steps protects the body from these potent agents.
Regulation (modifies) of PGs in body
2) Confidence 0.24 Published 1973 Journal J Reprod Med Section Abstract Doc Link 4571712 Disease Relevance 0 Pain Relevance 0.10
In contrast, paracetamol or carprofen, a novel NOSAC, fails to affect mucosal generation of PGs and does not influence gastric mucosal integrity.
Neg (fails) Regulation (affect) of PGs associated with paracetamol
3) Confidence 0.24 Published 1984 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6599541 Disease Relevance 0.58 Pain Relevance 0.27
Results of measurements of PGs showed that in the different weeks of gestation, the contents of PGs were essentially unchanged.
Neg (unchanged) Regulation (unchanged) of PGs
4) Confidence 0.24 Published 1974 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 4810040 Disease Relevance 0.26 Pain Relevance 0.09
Agonists and non-specific antagonists are used as pharmacological tools to investigate the inflammatory role of PGs, LTs, PAF, IL-1, histamine, complement, SP, PMN-leukocytes, and kallikrein-kininogen-kinin systems.
Spec (investigate) Regulation (role) of PGs in leukocytes associated with inflammation, antagonist and agonist
5) Confidence 0.16 Published 1990 Journal Exp Pathol Section Abstract Doc Link 1971600 Disease Relevance 0.98 Pain Relevance 0.55
These results are discussed with respect to the participation of PGs in neurodegenerative diseases (and its inhibition by NSAIDs) by affecting cytokine expression.
Regulation (participation) of PGs associated with cinod, neurodegenerative disease and cytokine
6) Confidence 0.11 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9003059 Disease Relevance 0.73 Pain Relevance 0.30
During placental malaria, modulation of these PGs pathway could play a role in preterm delivery and low birth weight as observed during pre-eclampsia.
Regulation (modulation) of PGs associated with malaria, birth weight, premature birth and eclampsia
7) Confidence 0.03 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 1.04 Pain Relevance 0.08
has a similar function in macrophages and adipocytes as it modulates lipid homeostasis in both cell types via regulation of genes including LPL (lipoprotein lipase), ACAT (acetyl coenzyme A acetyltransferase) and PLA (phospholipase A) genes, and the levels of FFAs (free fatty acids), PGs (prostaglandins), and LTs (leukotriens).
Regulation (regulation) of PGs in macrophages associated with obesity
8) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.59 Pain Relevance 0
They can interfere with PGs regulations and modulate the outcome of the pregnancy even if antenatal administration of celecoxib (a COX-2 inhibitor) seems to improve placental perfusion in the pregnant rabbit [28].
Regulation (regulations) of PGs associated with cox-2 inhibitor
9) Confidence 0.02 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 1.17 Pain Relevance 0.46
It seems likely that regulation of the transport of PGs through the plasma membrane (extracellular vs. intracellular) could be a mechanism for regulation of functional effects by luteal cell-derived PGs.
Regulation (regulation) of PGs in luteal cell
10) Confidence 0.01 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC293427 Disease Relevance 0 Pain Relevance 0
has a similar function in macrophages and adipocytes as it modulates lipid homeostasis in both cell types via regulation of genes including LPL (lipoprotein lipase), ACAT (acetyl coenzyme A acetyltransferase) and PLA (phospholipase A) genes, and the levels of FFAs (free fatty acids), PGs (prostaglandins), and LTs (leukotriens).
Regulation (regulation) of PGs in adipocytes associated with obesity
11) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.59 Pain Relevance 0
In fact, levels of proinflammatory/anti-inflammatory PGs have already been shown to be regulated by each other: previous studies have shown that 15d-PGJ2 is a potent blocker of mPGE synthase mRNA induction by LPS or IL-1?
Regulation (regulated) of PGs associated with inflammation
12) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 0.72 Pain Relevance 0.12

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