INT18361

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Context Info
Confidence 0.41
First Reported 1984
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.95
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocytes 1
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 87 99.98 Very High Very High Very High
COX2 5 99.08 Very High Very High Very High
antagonist 4 98.66 Very High Very High Very High
Inflammatory mediators 30 98.08 Very High Very High Very High
agonist 1 98.08 Very High Very High Very High
cytokine 8 94.52 High High
cINOD 80 92.96 High High
Pain 33 92.96 High High
Osteoarthritis 49 88.32 High High
tolerance 1 87.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 145 99.98 Very High Very High Very High
Phosphate Metabolism Disorders 110 99.84 Very High Very High Very High
Stress 39 97.44 Very High Very High Very High
Ulcers 2 97.44 Very High Very High Very High
Disease 28 95.76 Very High Very High Very High
Fever 2 95.00 High High
Apoptosis 43 93.72 High High
Pain 37 92.96 High High
Edema 5 91.52 High High
Increased Venous Pressure Under Development 4 90.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study indicates that the deficiency of endogenous PGs may play a role in the pathogenesis ulcer and that the degree of gastric mucosal damage by NOSAC is closely related to the alteration in the capability of the mucosa to generate PGs.
Positive_regulation (generate) of PGs associated with ulcers
1) Confidence 0.41 Published 1984 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6588526 Disease Relevance 0.71 Pain Relevance 0.23
High levels of prostaglandins (PGs) are currently found in tumoral cells, due to expression of the inducible PGs synthesis enzyme, the cyclooxygenase 2 (COX 2).
Positive_regulation (inducible) of PGs associated with cox2
2) Confidence 0.39 Published 2001 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 11352223 Disease Relevance 0.22 Pain Relevance 0.30
Agonists and non-specific antagonists are used as pharmacological tools to investigate the inflammatory role of PGs, LTs, PAF, IL-1, histamine, complement, SP, PMN-leukocytes, and kallikrein-kininogen-kinin systems.
Spec (investigate) Positive_regulation (role) of PGs in leukocytes associated with inflammation, antagonist and agonist
3) Confidence 0.31 Published 1990 Journal Exp Pathol Section Abstract Doc Link 1971600 Disease Relevance 0.98 Pain Relevance 0.55
Prostaglandins (PGs), which are generated by the enzymatic activity of cyclooxygenase (COX)-1 and -2, modulate several functions in the CNS such as the generation of fever, the sleep/wake cycle, and the perception of pain.
Positive_regulation (generated) of PGs associated with pain and fever
4) Confidence 0.15 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 11032891 Disease Relevance 0.42 Pain Relevance 0.12
Thus, physical activity seems to have a more positive impact on mineralization in HP than normalization of potentially elevated PGs alone.
Positive_regulation (elevated) of PGs associated with phosphate metabolism disorders
5) Confidence 0.14 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.72 Pain Relevance 0.20
Prostaglandins (PGs) are generated by the enzymatic activity of cyclooxygenase-1 and -2 (COX-1/2) and modulate several functions in the CNS such as the generation of fever, the sleep/wake cycle, and the perception of pain.
Positive_regulation (generated) of PGs associated with pain and fever
6) Confidence 0.13 Published 2006 Journal Neurochem. Int. Section Abstract Doc Link 16546299 Disease Relevance 0.55 Pain Relevance 0.31
To evaluate the efficacy of inhibitors, inhibition intensity on the production of inflammatory mediators is defined as:

where [PGs]1 is the concentration of PGs after taking drugs, [PGs]0 is the concentration of PGs before treatment, [LTs]1 is the concentration of LTs after taking drugs, and [LTs]0 is the concentration of LTs before treatment.


Positive_regulation (concentration) of PGs associated with inflammatory mediators
7) Confidence 0.12 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.10 Pain Relevance 0.05
The first 10 min was critical for the production of LTs, while PGs continued to accumulate with time.
Positive_regulation (accumulate) of PGs
8) Confidence 0.11 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC1829479 Disease Relevance 0.32 Pain Relevance 0.12
Thus, this study provides evidence that the elevation of PGs in HP might be based on the impaired clearance of calcium pyrophosphate resulting from alkaline phosphatase deficiency.
Positive_regulation (elevation) of PGs associated with phosphate metabolism disorders
9) Confidence 0.10 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.70 Pain Relevance 0.17
PGs are derived from arachidonic acid (AA) through the actions of the COX enzymes, which are rate-limiting.
Positive_regulation (derived) of PGs
10) Confidence 0.03 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.41 Pain Relevance 0.03
Once formed by COX-1 or COX-2, the unstable PGH2 intermediate is metabolized by specific PG synthase enzymes to generate the classical bioactive PGs, including PGE2, PGD2, PGF2?
Positive_regulation (generate) of PGs
11) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.42 Pain Relevance 0.22
Cyclooxygenase (COX) derived PGs have two distinct membrane-anchored isoenzymes, COX-1 and COX-2.
Positive_regulation (derived) of PGs
12) Confidence 0.02 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.40 Pain Relevance 0.12

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