INT183614

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.13
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ESR1, TMED4) nucleoplasm (ESR1) endoplasmic reticulum (TMED4)
enzyme binding (ESR1) DNA binding (ESR1) protein complex (ESR1)
ESR1 (Homo sapiens)
TMED4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 56.76 Quite High
antagonist 1 35.48 Quite Low
cytokine 6 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Postmenopausal Osteoporosis 4 70.00 Quite High
Breast Cancer 9 55.92 Quite High
Apoptosis 58 50.00 Quite Low
Endometriosis (extended) 6 29.08 Quite Low
Hypercalcemia 10 15.20 Low Low
Osteoporosis 28 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Hyperplasia 4 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogens diffuse into cells and binds to the ERs, triggering ER dimerization as well as a specific conformational change (Jensen 1991).
ER Binding (binds) of ERs
1) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684086 Disease Relevance 0.13 Pain Relevance 0.03
Among the specific hormone receptors involved, two estrogen receptors (ERs) are of particular interest: ER-?
ER Binding (interest) of ERs
2) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1143573 Disease Relevance 0 Pain Relevance 0

General Comments

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