INT183626

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Ctnnd2) nucleus (Ctnnd2)
Anatomy Link Frequency
nucleus 2
T-cell 1
Ctnnd2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 5 50.00 Quite Low
cytokine 4 46.12 Quite Low
Inflammation 25 45.72 Quite Low
cINOD 8 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 26 98.52 Very High Very High Very High
Adhesions 2 96.32 Very High Very High Very High
Colon Cancer 23 94.40 High High
Adenocarcinoma 23 91.88 High High
Adenoma 33 90.68 High High
Apoptosis 20 88.88 High High
Ovarian Cancer 2 80.92 Quite High
Colorectal Cancer 18 73.00 Quite High
Breast Cancer 8 70.92 Quite High
Hyperplasia 5 62.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin translocation from the cytoplasm into the nucleus [42-44]. ?
Localization (translocation) of catenin in nucleus
1) Confidence 0.73 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.49 Pain Relevance 0
-catenin itself leading to nuclear translocation and binding to TCF4 (T-cell Factor 4).
Localization (translocation) of catenin in T-cell
2) Confidence 0.73 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.74 Pain Relevance 0
-catenin, a protein targeted by GSK3?
Localization (targeted) of catenin
3) Confidence 0.73 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
-catenin interacts with T-cell factor (Tcf) or lymphoid-enhancer factor (Lef) and translocates to the nucleus, in which it transactivates target genes including c-myc and cyclin D1 that are the potentially oncogenic [47,60] in the cytoplasm or nucleus as a consequence of mutant Apc or ?
Localization (translocates) of catenin in nucleus
4) Confidence 0.68 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1156872 Disease Relevance 1.05 Pain Relevance 0

General Comments

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