INT183629

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 11.78
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Ctnnd2) nucleus (Ctnnd2)
Anatomy Link Frequency
colon 2
nucleus 1
embryonic kidney 1
Ctnnd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 95.44 Very High Very High Very High
COX-2 inhibitor 31 92.64 High High
cytokine 30 91.92 High High
Inflammation 125 59.92 Quite High
agonist 19 58.80 Quite High
cINOD 60 51.36 Quite High
chemokine 2 42.32 Quite Low
aspirin 7 11.84 Low Low
Bile 14 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 192 100.00 Very High Very High Very High
Colon Cancer 317 99.80 Very High Very High Very High
Familial Adenomatous Polyposis 553 99.60 Very High Very High Very High
Cancer 617 99.52 Very High Very High Very High
Adenocarcinoma 126 99.52 Very High Very High Very High
Malignant Neoplastic Disease 41 99.36 Very High Very High Very High
Ovarian Cancer 7 99.28 Very High Very High Very High
Intestinal Polyps 17 97.32 Very High Very High Very High
Apoptosis 158 95.72 Very High Very High Very High
INFLAMMATION 119 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin expression was seen in the nucleus and cytoplasm of adenocarcinoma cells (Figure 3c).
Gene_expression (expression) of catenin in nucleus associated with adenocarcinoma
1) Confidence 0.75 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1156872 Disease Relevance 1.15 Pain Relevance 0
-catenin levels and colon carcinogenesis during the early steps of tumor formation [21].
Gene_expression (levels) of catenin in colon associated with cancer
2) Confidence 0.65 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1156872 Disease Relevance 1.27 Pain Relevance 0
-catenin levels alter its transcriptional activity during a period of defective embryonic kidney growth during development.
Gene_expression (levels) of catenin in embryonic kidney
3) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0.13 Pain Relevance 0
-catenin pathways
Gene_expression (pathways) of catenin
4) Confidence 0.65 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.84 Pain Relevance 0.16
-catenin in adenomas as well as in adenocarcinomas using the same experimental model.[7375] In human colon cancer, the cytosolic accumulation of ?
Gene_expression (adenomas) of catenin in colon associated with adenocarcinoma, adenoma and colon cancer
5) Confidence 0.65 Published 2010 Journal Journal of Carcinogenesis Section Body Doc Link PMC2862504 Disease Relevance 0.92 Pain Relevance 0.06
-catenin destruction; loss of APC function increases transcription of ?
Gene_expression (destruction) of catenin associated with familial adenomatous polyposis
6) Confidence 0.65 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.05 Pain Relevance 0
-catenin targets c-myc, c-jun and cyclin D1 were evident in Irs2-/- kidneys (Fig. 7D).


Gene_expression (targets) of catenin
7) Confidence 0.65 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
-catenin is an adherens junction protein with altered expression in various tumor types.
Gene_expression (expression) of catenin associated with cancer
8) Confidence 0.65 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0.61 Pain Relevance 0
-catenin expression levels in colorectal
Gene_expression (expression) of catenin
9) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.98 Pain Relevance 0.03
-catenin target genes including c-myc are expressed.
Gene_expression (expressed) of catenin
10) Confidence 0.58 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.06 Pain Relevance 0
-catenin expression levels in the colonic
Gene_expression (expression) of catenin
11) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 0.91 Pain Relevance 0.03
-catenin, COX-2 and iNOS expression in colonic adenocarcinomas are given in Table 4. ?
Gene_expression (expression) of catenin associated with adenocarcinoma
12) Confidence 0.58 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1156872 Disease Relevance 0.78 Pain Relevance 0.03
-catenin expression in colorectal adenocarcinomas.
Gene_expression (expression) of catenin associated with adenocarcinoma
13) Confidence 0.58 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1156872 Disease Relevance 0.47 Pain Relevance 0.05
-catenin was not detected in other tissues; again suggesting that defects in PKB/Akt/GSK3?
Neg (not) Gene_expression (detected) of catenin
14) Confidence 0.58 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
-catenin expression in the colonic malignancy.


Gene_expression (expression) of catenin associated with malignant neoplastic disease
15) Confidence 0.58 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1156872 Disease Relevance 0.73 Pain Relevance 0.08
-catenin expression was restricted to the cytoplasm in the sporadic patients lacking CTNNB1 mutations.
Gene_expression (expression) of catenin
16) Confidence 0.58 Published 2007 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2736982 Disease Relevance 0.87 Pain Relevance 0.05

General Comments

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